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- W2183618524 abstract "The aim of present research was to develop a fast releasing oral polymeric film, with good mechanical properties, instant disintegration and dissolution, producing an acceptable taste when placed on tongue. Solvent casting method was used to prepare oral films. Levocetirizine dihydrochloride, an antihistaminic was the drug incorporated to relieve the symptoms of allergic rhinitis. The polymers selected were Eudragit EPO, HPMC E 5 LV and PVA. Glycerin, dibutyl phthalate, propylene glycol and PEG 400 were the plasticizers used. Four batches of films with drug were prepared using different combinations of polymers and plasticizers. The resultant films were evaluated for weight variation, assay, content uniformity, folding endurance, thickness, tensile strength, percent elongation, surface pH, in vitro disintegration and in vitro dissolution. The formulations from the preliminary trail was taken and Taguchi OA experimental design was applied to optimize type of polymers, concentration of polymers, plasticizer, and sweetener based on their disintegration data at their three different levels. The optimized films which disintegrated in less than 30 sec, releasing 70-90% of drug within 2 minutes. The percentage release was varying with type of polymer and concentration of polymer. The films made with EPO released 96 % of drug in 2 min, which was the best release amongst all." @default.
- W2183618524 created "2016-06-24" @default.
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- W2183618524 date "2011-01-01" @default.
- W2183618524 modified "2023-09-26" @default.
- W2183618524 title "FORMULATION DEVELOPMENT OF FAST RELEASING ORAL THIN FILMS OF LEVOCETRIZINE DIHYDROCHLORIDE WITH EUDRAGIT EPO AND OPTIMISATION THROUGH TAGUCHI ORTHOGONAL EXPERIMENTAL DESIGN Research Article" @default.
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