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- W2183618907 abstract "Background: Bone morphogenetic proteins (BMPs) are involved in cartilage and bone formation. However, the association between single nucleotide polymorphisms (SNPs) of BMP genes and degenerative lumbar scoliosis (DLS) has not been investigated yet. The aim of this study was to determine whether coding SNPs (cSNPs) of BMP genes (BMP2, 3, 4, 5, 6, and 10) are associated with DLS in Korean population. Methods: Seven cSNPs in BMP genes were selected and genotyped for 66 patients with DLS and 127 healthy controls using direct sequencing. Results: Of the SNPs examined, two cSNPs of BMP2 gene showed weak associations with DLS in the codominant (rs235768, Arg190Ser, missense, OR = 2.28, 95% CI = 1.19 – 4.36, p = 0.03) and dominant models (rs235768, OR = 1.99, 95% CI = 1.07 – 3.72, p = 0.03; rs1049007, Ser87Ser, synonymous, OR = 1.93, 95% CI = 1.039 – 3.62, p = 0.04). Conclusion: BMP2 may be a susceptible gene for DLS in Korean population." @default.
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- W2183618907 date "2014-01-01" @default.
- W2183618907 modified "2023-09-27" @default.
- W2183618907 title "Association between cSNPs of BMP2 Gene and Degenerative Lumbar Scoliosis in Korean Population" @default.
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