Matches in SemOpenAlex for { <https://semopenalex.org/work/W2183621435> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2183621435 abstract "Circadian rhythms, characterized by a period of about 24h, are generated in nearly all living organisms by the negative autoregulation of clock gene expression. Deterministic models based on this genetic regulation account for circadian oscillations in constant environmental conditions (e.g., in constant darkness) and for entrainment of these rhythms by light–dark cycles. When the number of clock mRNA and protein molecules is low, it is necessary to resort to stochastic simulations to assess the influence of molecular noise on circadian oscillations. Indeed, it is possible that the autoregulatory mechanism of gene expression might not produce stable rhythms due to fluctuations if the number of molecules involved in the clock mechanism remains too low. We have compared the deterministic and stochastic approaches for a model based on the negative autoregulation of a clock gene. We show by means of stochastic simulations that robust circadian oscillations can already occur when the maximum number of mRNA and protein molecules is of the order of a few tens or hundreds, respectively. Furthermore, the results indicate that the cooperativity characterizing the repression of the transcription process strenghtens the robustness of circadian rhyth ms and that entrainment by light–dark cycles stabilizes the phase of the oscillations. © 2003 Editions scientifiques et medicales Elsevier SAS. Tous droits reserves. Mots cles : Bruit moleculaire ; Modelisation ; Rythme circadien" @default.
- W2183621435 created "2016-06-24" @default.
- W2183621435 creator A5001500450 @default.
- W2183621435 creator A5027310438 @default.
- W2183621435 creator A5059875969 @default.
- W2183621435 date "2003-01-01" @default.
- W2183621435 modified "2023-09-27" @default.
- W2183621435 title "Modèles déterministes et stochastiques pour les rythmes circadiens Deterministic and stochastic models for circadian rhythms" @default.
- W2183621435 cites W1530371171 @default.
- W2183621435 cites W1557148833 @default.
- W2183621435 cites W1575619134 @default.
- W2183621435 cites W1946177469 @default.
- W2183621435 cites W1978319180 @default.
- W2183621435 cites W1979385177 @default.
- W2183621435 cites W1981166024 @default.
- W2183621435 cites W1995397995 @default.
- W2183621435 cites W2002251982 @default.
- W2183621435 cites W2045636894 @default.
- W2183621435 cites W2066440682 @default.
- W2183621435 cites W2084772782 @default.
- W2183621435 cites W2088907143 @default.
- W2183621435 cites W2101546531 @default.
- W2183621435 cites W2105640293 @default.
- W2183621435 cites W2118809524 @default.
- W2183621435 cites W2150313602 @default.
- W2183621435 cites W2155418451 @default.
- W2183621435 hasPublicationYear "2003" @default.
- W2183621435 type Work @default.
- W2183621435 sameAs 2183621435 @default.
- W2183621435 citedByCount "0" @default.
- W2183621435 crossrefType "journal-article" @default.
- W2183621435 hasAuthorship W2183621435A5001500450 @default.
- W2183621435 hasAuthorship W2183621435A5027310438 @default.
- W2183621435 hasAuthorship W2183621435A5059875969 @default.
- W2183621435 hasConcept C104317684 @default.
- W2183621435 hasConcept C112795245 @default.
- W2183621435 hasConcept C121332964 @default.
- W2183621435 hasConcept C121446783 @default.
- W2183621435 hasConcept C1276947 @default.
- W2183621435 hasConcept C130679736 @default.
- W2183621435 hasConcept C135343436 @default.
- W2183621435 hasConcept C139992725 @default.
- W2183621435 hasConcept C169760540 @default.
- W2183621435 hasConcept C184738001 @default.
- W2183621435 hasConcept C201176492 @default.
- W2183621435 hasConcept C24890656 @default.
- W2183621435 hasConcept C2778880379 @default.
- W2183621435 hasConcept C38606739 @default.
- W2183621435 hasConcept C54355233 @default.
- W2183621435 hasConcept C63479239 @default.
- W2183621435 hasConcept C78458016 @default.
- W2183621435 hasConcept C86803240 @default.
- W2183621435 hasConceptScore W2183621435C104317684 @default.
- W2183621435 hasConceptScore W2183621435C112795245 @default.
- W2183621435 hasConceptScore W2183621435C121332964 @default.
- W2183621435 hasConceptScore W2183621435C121446783 @default.
- W2183621435 hasConceptScore W2183621435C1276947 @default.
- W2183621435 hasConceptScore W2183621435C130679736 @default.
- W2183621435 hasConceptScore W2183621435C135343436 @default.
- W2183621435 hasConceptScore W2183621435C139992725 @default.
- W2183621435 hasConceptScore W2183621435C169760540 @default.
- W2183621435 hasConceptScore W2183621435C184738001 @default.
- W2183621435 hasConceptScore W2183621435C201176492 @default.
- W2183621435 hasConceptScore W2183621435C24890656 @default.
- W2183621435 hasConceptScore W2183621435C2778880379 @default.
- W2183621435 hasConceptScore W2183621435C38606739 @default.
- W2183621435 hasConceptScore W2183621435C54355233 @default.
- W2183621435 hasConceptScore W2183621435C63479239 @default.
- W2183621435 hasConceptScore W2183621435C78458016 @default.
- W2183621435 hasConceptScore W2183621435C86803240 @default.
- W2183621435 hasLocation W21836214351 @default.
- W2183621435 hasOpenAccess W2183621435 @default.
- W2183621435 hasPrimaryLocation W21836214351 @default.
- W2183621435 isParatext "false" @default.
- W2183621435 isRetracted "false" @default.
- W2183621435 magId "2183621435" @default.
- W2183621435 workType "article" @default.