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- W2183623151 abstract "Summary: It has been suggested that oxidative stress defined as a shift in antioxidant/oxidant balance towards oxidants is associated with the pathogenesis of many diseases, including carcinogenesis. Reactive oxygen spe cies can induce carcinogenesis via injury to macro mo lecules such as DNA, carbohydrates and proteins. Forty pri ma ry gastric carcinoma patients and 40 healthy controls were included in the study. Advanced oxidation protein products, total thiols, total protein, albumin in plasma, % hemolysis in RBC suspension and glutathione in both whole blood and plasma were estimated. Our studies de mon strated a significant increase in advanced oxidation protein products, % hemo ly sis (p=0.033), A:G ratio (p=0.003) and a highly significant decrease in blood glutathione (p=0.036), total thiols (p=0.001), plasma thiols other than glutathione and total antioxidant activity. The findings suggest that gastric carci noma is associated with oxygen derived free radicals accumulation, and depletion of total antioxidant activity has lead to oxidative stress and advancement of oxidative-antioxidative disorders followed by progression of gastric cancer." @default.
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- W2183623151 date "2010-01-01" @default.
- W2183623151 modified "2023-09-26" @default.
- W2183623151 title "OXIDATIVE PRODUCTS OF PROTEINS AND ANTIOXIDANT POTENTIAL OF THIOLS IN GASTRIC CARCINOMA PATIENTS PROIZVODI OKSIDACIJE PROTEINA I ANTIOKSIDATIVNI POTENCIJAL TIOLA KOD OBOLELIH OD GASTRI^NOG KARCINOMA" @default.
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