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• W2183625058 abstract "Visceral leishmaniasis (VL) is characterized by a depression of the T helper cell type 1 immune response. Although mRNA expression for interleukin-4 (IL-4) is observed, evidence of the role of this cytokine in the pathogenesis of VL has been lacking. Since IL-4 is involved in IgE synthesis, we measured the total IgE and Leishmania antigen-specific IgE antibody levels in sera from patients with VL. Specific IgE antibodies detected by an ELISA technique after absorbing the sera with purified sheep IgG anti-human IgG were found in all 23 patients with VL and were not detected in subjects with subclinical Leishmania chagasi infection (n = 10), Chagas' disease (n = 10), atopic patients (n = 10), and healthy controls (n = 10). Levels of Leishmania-specific IgE (optical density values) before and after treatment were 0.100 +/- 0.03 (mean +/- SD) and 0.028 +/- 0.002, respectively (P < 0.05). These results indicate that a specific IgE response is useful in the diagnosis of active disease and to evaluate response to treatment." @default.
• W2183625058 created "2016-06-24" @default.
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• W2183625058 date "1998-09-01" @default.
• W2183625058 modified "2023-10-17" @default.
• W2183625058 title "Anti-leishmanial IgE antibodies: a marker of active disease in visceral leishmaniasis." @default.
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• W2183625058 doi "https://doi.org/10.4269/ajtmh.1998.59.426" @default.
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