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- W2183628714 abstract "Abhrak bhasma, an Ayurvedic drug used against many diseases including hepatitis. In present study various doses of abhrak bhasma (10, 20, 30 and 40 mg/kg body wt) were tested for hepatoprotective efficacy against carbon tetrachloride (CCl 4 ) intoxicated liver and kidney functions in male albino rat. Administration of CCl 4 to the normal rat increased serum levels of AST, ALT, ALP and bilirubin indicated acute damage. Abhrak bhasma treatment counteracted the action of CCl 4 on liver and kidney functions. With the administration of increasing doses of abhrak bhasma all activities were dropped progressively and significantly at 40 mg dose as compared with silicate control. Conjugation metabolism and excr etion of bilirubin were improved with increasing doses of abhrak bhasma suggesting dose dependent p rotection of all metabolic steps in bilirubin metabolism. Also CCl 4 induced acute toxicity increased serum urea and creatinine content, which was progressively controlled by increasing abhrak b hasma doses. The findings of this study indicated that abhrak b hasma exert dose dependent protective effects in liver and kidneys functions against CCl 4 induced toxicity in albino rat." @default.
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- W2183628714 date "2013-10-27" @default.
- W2183628714 modified "2023-10-15" @default.
- W2183628714 title "ABHRAK BHASMA MEDIATED ALTERATIONS IN LIVER AND KIDNEY FUNCTIONS IN MALE ALBINO RATS DURING CARBON TETRACHLORIDE INDUCED TOXICITY" @default.
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- W2183628714 doi "https://doi.org/10.7897/2277-4343.04514" @default.
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