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• W2183633076 abstract "In the present study, a novel thiazoles were synthesized by incorporation of pyrazole moiety at 2 nd position of 2-hydrazinyl-N-(4-phenylthiazol-2-yl) acetamide (5) by treating with chalcones (7a-7j). The chemical structures of the synthesized compounds were confirmed by means of IR, 1 H-NMR, Mass spectral and Elemental analysis. These compounds were screened for anti-bacterial ( Staphylococcus aureus ATCC 9144 , Staphylococcus epidermidis ATCC 155 , Micrococcus luteus ATCC 4698, Bacillus cereus ATCC 11778 , Escherichia coli ATCC 25922 , Pseudomonas aeruginosa ATCC 2853 , and Klebsiella pneumoniae ATCC 11298 )) and anti-fungal ( Aspergillus niger ATCC 9029 and Aspergillus fumigatus ATCC 46645) activities by paper disc diffusion technique. Most of the synthesized compounds exhibited significant anti-bacterial and anti-fungal activities. Among the synthesized compounds, 2-(5-(4-hydroxyphenyl)-3-phenyl-4,5-dihydropyrazol-1-yl)-N-(4phenylthiazol-2-yl)acetamide (8f) was found to exhibit the highest anti-bacterial activity and 2-(5-(4hydroxy-3-methoxyphenyl)-3-phenyl-4,5-dihydropyrazol-1-yl)-N-(4-phenylthiazol-2-yl)acetamide (8j) exhibited highest anti-fungal activity." @default.
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• W2183633076 date "2010-01-01" @default.
• W2183633076 modified "2023-09-27" @default.
• W2183633076 title "Synthesis, Characterization and Anti-Microbial Activities of Novel Thiazole Derivatives" @default.
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