Matches in SemOpenAlex for { <https://semopenalex.org/work/W2183633601> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2183633601 abstract "Oritavancin is a semisynthetic lipoglycopeptide currently under clinical development for the treatment of acute bacterial skin and skin structure infections (ABSSSI) in adult patients. Potent in vitro activity against Gram-positive organisms, including vancomycin-resistant enterococci (VRE) and Staphylococcus aureus (VRSA), has been demonstrated for this compound in recent investigational and surveillance reports. This in vitro activity is attributed to multiple mechanisms of action which include inhibition of cell wall synthesis at the level of both transglycosylation and transpeptidation, increase of membrane permeability and effect on the transmembrane electrochemical potential and possibly partial inhibition of RNA synthesis. The combination of these mechanisms provides oritavancin with a rapidly bactericidal and concentration-dependent killing. The objective of this study was to evaluate the activities of oritavancin and comparators tested against βhaemolytic streptococci (BHS) clinical isolates from Europe." @default.
- W2183633601 created "2016-06-24" @default.
- W2183633601 creator A5008542312 @default.
- W2183633601 creator A5037843249 @default.
- W2183633601 creator A5044679653 @default.
- W2183633601 creator A5061962262 @default.
- W2183633601 date "2011-01-01" @default.
- W2183633601 modified "2023-09-27" @default.
- W2183633601 title "Assessment of Oritavancin Activity Tested Against β-haemolytic Streptococci Responsible for Skin and Skin Structure Infections in Europe (2008-2010)" @default.
- W2183633601 hasPublicationYear "2011" @default.
- W2183633601 type Work @default.
- W2183633601 sameAs 2183633601 @default.
- W2183633601 citedByCount "0" @default.
- W2183633601 crossrefType "journal-article" @default.
- W2183633601 hasAuthorship W2183633601A5008542312 @default.
- W2183633601 hasAuthorship W2183633601A5037843249 @default.
- W2183633601 hasAuthorship W2183633601A5044679653 @default.
- W2183633601 hasAuthorship W2183633601A5061962262 @default.
- W2183633601 hasConcept C185592680 @default.
- W2183633601 hasConcept C202751555 @default.
- W2183633601 hasConcept C2775983603 @default.
- W2183633601 hasConcept C2778980435 @default.
- W2183633601 hasConcept C2779489039 @default.
- W2183633601 hasConcept C2908866784 @default.
- W2183633601 hasConcept C523546767 @default.
- W2183633601 hasConcept C54355233 @default.
- W2183633601 hasConcept C55493867 @default.
- W2183633601 hasConcept C71924100 @default.
- W2183633601 hasConcept C86803240 @default.
- W2183633601 hasConcept C89423630 @default.
- W2183633601 hasConcept C98274493 @default.
- W2183633601 hasConceptScore W2183633601C185592680 @default.
- W2183633601 hasConceptScore W2183633601C202751555 @default.
- W2183633601 hasConceptScore W2183633601C2775983603 @default.
- W2183633601 hasConceptScore W2183633601C2778980435 @default.
- W2183633601 hasConceptScore W2183633601C2779489039 @default.
- W2183633601 hasConceptScore W2183633601C2908866784 @default.
- W2183633601 hasConceptScore W2183633601C523546767 @default.
- W2183633601 hasConceptScore W2183633601C54355233 @default.
- W2183633601 hasConceptScore W2183633601C55493867 @default.
- W2183633601 hasConceptScore W2183633601C71924100 @default.
- W2183633601 hasConceptScore W2183633601C86803240 @default.
- W2183633601 hasConceptScore W2183633601C89423630 @default.
- W2183633601 hasConceptScore W2183633601C98274493 @default.
- W2183633601 hasLocation W21836336011 @default.
- W2183633601 hasOpenAccess W2183633601 @default.
- W2183633601 hasPrimaryLocation W21836336011 @default.
- W2183633601 hasRelatedWork W1946864845 @default.
- W2183633601 hasRelatedWork W2005472407 @default.
- W2183633601 hasRelatedWork W2034443922 @default.
- W2183633601 hasRelatedWork W2068336213 @default.
- W2183633601 hasRelatedWork W2134266580 @default.
- W2183633601 hasRelatedWork W2144069506 @default.
- W2183633601 hasRelatedWork W2165630515 @default.
- W2183633601 hasRelatedWork W2170502318 @default.
- W2183633601 hasRelatedWork W2182840576 @default.
- W2183633601 hasRelatedWork W2469403524 @default.
- W2183633601 hasRelatedWork W2474255949 @default.
- W2183633601 hasRelatedWork W2550673090 @default.
- W2183633601 hasRelatedWork W2800757323 @default.
- W2183633601 hasRelatedWork W2894897374 @default.
- W2183633601 hasRelatedWork W2956579761 @default.
- W2183633601 hasRelatedWork W2995895130 @default.
- W2183633601 hasRelatedWork W3038123490 @default.
- W2183633601 hasRelatedWork W3098808161 @default.
- W2183633601 hasRelatedWork W3110914523 @default.
- W2183633601 hasRelatedWork W2463247760 @default.
- W2183633601 isParatext "false" @default.
- W2183633601 isRetracted "false" @default.
- W2183633601 magId "2183633601" @default.
- W2183633601 workType "article" @default.