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- W2183634501 abstract "Summary D. pentagyna is a herbal plant which is most commonly used as traditional herbal medicine in cancer suspected cases by the Mizo tribe in Mizoram state, India. The objective of the present study was to evaluate the changes in the levels of glutathione and its related enzymes in tumor cells and other tissues of the host so as to explore their possible role in its antitumor activity. Treatment of ascites Dalton’s lymphoma-bearing mice with methanol extract of Dillenia pentagyna at a dose of 20 mg/kg body weight showed antitumor potential. Plant extract treatment causes an increase in the level of glutathione in kidney, spleen and testes while a significant decrease was found in liver and Dalton’s lymphoma (DL) cells. The assay of glutathione-s-transferase (GST) and glutathione reductase (GR) activities in Dalton’s lymphoma cells showed that the treatment caused an increase in GST activity and a decrease in GR activity. It is proposed that the decreased level of GSH may partially be due to decreased GR activity in Dalton’s lymphoma cells, and may contribute to the antitumor potential of Dillenia pentagyna. However, other contributory steps may also be involved in the antitumor activity of D. pentagyna and further investigation is needed in this direction." @default.
- W2183634501 created "2016-06-24" @default.
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- W2183634501 date "2007-01-01" @default.
- W2183634501 modified "2023-09-27" @default.
- W2183634501 title "CHANGES IN ENDOGENOUS GLUTATHIONE LEVEL ASSOCIATED WITH THE ANTITUMOR ACTIVITY OF THE STEM BARK EXTRACT OF DILLENIA PENTAGYNA AGAINST MURINE ASCITES DALTON'S LYMPHOMA" @default.
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