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• W2183634832 abstract "The effect of the pesticide deltamethrin on cytosolic free Ca ²⁺ concentrations ([Ca²⁺ ]i) and viability in human glioblastoma DBTRG-05MG cells is explored. [Ca²⁺ ]i was measured in suspended cells using fura-2 as a Ca²⁺ -sensitive fluorescent dye. Deltamethrin at concentrations of 5-60 μM increased [Ca²⁺]i in a concentration-dependent fashion. The Ca²⁺ signal was reduced partly by removing extracellular Ca ²⁺ . Deltamethrin induced Mn ²⁺ entry leading to quenching of fura-2 fluorescence. Deltamethrin-induced [Ca²⁺ ]i rise was not inhibited by nifedipine, econazole, SKF96365, and phorbol 12-myristate 13 acetate, but was inhibited by the protein kinase C (PKC) inhibitor GF109203X via blocking Ca²⁺ release. In Ca²⁺ -free medium, 50 μM deltamethrin pretreatment abolished the [Ca²⁺]i rise induced by the endoplasmic reticulum Ca²⁺ pump inhibitor thapsigargin (TG) or 2,5-di-tertbutylhydroquinone (BHQ). Conversely, pretreatment with TG/BHQ abolished deltamethrin-induced [Ca²⁺]i rise. Inhibition of inositol 1,4,5-trisphosphate formation with U73122 suppressed 50% of deltamethrin-induced [Ca²⁺]i rise. At concentrations between 10 and 80 μM deltamethrin killed cells in a concentration-dependent manner. The cytotoxic effect of deltamethrin was not reversed by prechelating cytosolic Ca²⁺ with 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (BAPTA). Annexin V/ propidium iodide staining data suggest that deltamethrin (10-40 μM) induced apoptosis in a concentrationdependent manner. Deltamethrin also increased levels of reactive oxygen species. Together, in human glioblastoma cells, deltamethrin induced a [Ca²⁺]i rise by inducing phospholipase C- and PKC-dependent Ca²⁺ release from the endoplasmic reticulum and Ca²⁺ entry via non-store-operated Ca²⁺ channels. Deltamethrin induced cell death that might involve apoptosis via mitochondrial pathways." @default.
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• W2183634832 date "2012-01-01" @default.
• W2183634832 modified "2023-10-16" @default.
• W2183634832 title "Deltamethrin-Induced [Ca2+ ]i Rise and Death in HGB Human Glioblastoma Cells" @default.
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• W2183634832 doi "https://doi.org/10.4077/cjp.2012.bab114" @default.
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