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- W2183635934 abstract "(H3N2)(CR48)virus. Noclinically significant morbidity or decrement inpulmonary function occurred postvaccination. Two(15%)recipients ofCR37virus andtwelve (44%)recipients ofCR48virus becameinfected withvaccine virus, asindicated bya fourfold riseinserum hemagglutination inhibition antibody titer; afourfold rise inserum immunoglobulin G (IgG) or IgAantibody titer, indicated byenzyme-linked immunosorbent assay;isolation ofvaccine virus fromnasal washings; or all ofthese. Within 1yearafter cold-recombinant vaccine virus vaccination, 18vaccinees received inactivated trivalent influenza virus vaccine parenterally. Ofthevaccinees, 13(72%)developed a fourfold rise inserum antibody titer toHlNlantigen and16(89%)developed afourfold rise inserum antibody titer toH3N2antigen. Weconclude that administration ofthese cold-recombinant vaccine viruses toolder adults withchronic diseases was safe, butthatserum antibody responserateswere lowerthanthoseachieved withsubsequently administered inactivated influenza virus vaccine givenparenterally. However, thehigher seroconversion rates attained byusing theinactivated trivalent influenza virus vaccine donotnecessarily mean thatitismore efficacious inpreventing infection or severeillness orbothduetonatural wild-type influenza A virus. Before eachrespiratory disease season,itisrecommended that populations athighrisk forcomplications resulting from influenza virusinfection beimmunized against theprevalent strains ofinfluenza viruses (11,12). Thepurpose ofthis immunization istoreducemortality andmorbidity from influenza illness andpneumonia (either primary viral or secondary bacterial pneumonia). Amongthoserecommendedtoreceive influenza vaccine are persons over the age of65yearsandpatients withchronic lung, heart, or metabolic disease. Despite adocumented needforinfluenza immunization inthese populations, compliance may below andtheefficacy ofinactivated influenza virus vaccine may belowerintheelderly thaninyoungerpersons(26). The fourfold rateofserologic responsetoinactivated virus parenteral vaccines hasranged from70to90%,andin certain elderly subpopulations theresponseratehasbeenas lowas21%(4,8,9,16-18, 21,26,28,31). Previous influenza virus vaccination appearstodecrease therateofserologic responsetosubsequent vaccination aswell(8). Intranasally administered live-attenuated, cold-recombinant (CR)influenza A virus vaccines offer a potentially more desirable andeffective approach toimmunization against influenza A virus infection. CR virus vaccines donot require parenteral injection andoffer thetheoretical advantageofstimulating secretory immunoglobulin A (IgA) antibodyproduction atthenatural portal ofentry(31). Neutralizing IgAantibody and,toalesser extent, IgGantibody are present innasal washspecimens takenfromvolunteers who are resistant tochallenge withinfluenza A. The antihemagglutinin serum IgAantibody level may correlate with theproduction ofsecretory IgAintherespiratory tract, perhaps duetotheescapeoflocally produced IgAantibody fromthenasal mucosa into thesystemic circulation (10, 24)." @default.
- W2183635934 created "2016-06-24" @default.
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- W2183635934 date "1986-01-01" @default.
- W2183635934 modified "2023-09-26" @default.
- W2183635934 title "Safety ofandSerumAntibody Response toCold-Recombinant Influenza A andInactivated Trivalent Influenza VirusVaccines in OlderAdults withChronic Diseases" @default.
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