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- W2183638150 abstract "Serum levels of testosterone and sex-hormone binding globulin (SHBG) were measured in 31 patients with breast carcinoma and 33 patients with carcinoma of the uterine cervix along with 30 healthy (control) women. Amongst the patients of breast cancer, significantly higher level of testosterone and a low level of SHBG were found in comparison with the other two groups. The study has revealed th at testosterone and SHBG may have an indirect rol e in breast cancer, probably through their influences on th e amount of bioavailable estrogen. Carcinoma of the breast ranks as the second most common cancer in women in Indi a. Several lines of research suggest that reproductive hormones influence the risk of breast cancer'·'. The major sites of endogenous estrogen biosynthesis are the ovarian granulosa cells in premenopausal women and extraovarian adipose tissues in postmenopausal women. Androgens are converted into estrogen (aromatization) by the enzyme complex, aromatase in the above mentioned tissues . Increased peripheral conversion of adrenal androgens into estrogens in obese women is presumed to increase the risk. Therefore, obese postmenopausal women may be at ' higher risk' for breast cancer than postmenopausal women who are not obese. But there are many reports in which no correlation between endogenous hormones and the risk of breast cancer could be demonstrated. There are also several reports 4 - 6 of women with breast cancer having higher levels of nonprotein-bound estrogens 4 ' 5 and lower level of SHBG in blood. Although more consistent results have been found in case-control studies on urinary or serum levels of testosterone, it is doubtful whether it is due to the stress associated with cancer 7 . Hence , it may be more appropriate to compare the findings with another cancer as control. Many of the risk factors for cancer of the breast appear to be the inverse of those for cancer of · the uterine cervix 7 which is the" @default.
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- W2183638150 date "2000-08-01" @default.
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- W2183638150 title "A comparative study on serum levels of testosterone and SHBG in carcinomas of breast and uterine cervix" @default.
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