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• W2183639023 abstract "Adenosine is an endogenous modulator of synaptic functions in the central nervous system. To investigate the physiologic and pathologic roles of the adenosine receptors in the human brain, PET is a powerful in vivo technique. In this study, we quantitatively evaluated the distribution of a major subtype A1 adenosine receptor in the human brain by PET with a newly developed radioligand, 8-dicyclopropylmethyl-1- 11 C-methyl-3-propylxanthine ( 11 C-MPDX). Methods: In 5 healthy volunteers, after PET measurement of the regional cerebral blood flow (rCBF) with 15 O-H2O, a 60-min PET scan with 11 C-MPDX was performed. The distribution volume (DV) of 11C-MPDX was quantitatively evaluated by Logan’s graphical analysis. Results: 11 C-MPDX was taken up at a high level, reaching a peak at 2‐2.5 min, followed by a rapid decrease. The unchanged form of 11CMPDX in plasma was 75% at 60 min after injection. The DV of 11C-MPDX was large in the striatum and thalamus, moderate in the cerebral cortices and pons, and small in the cerebellum. The distribution pattern of 11 C-MPDX in the brain was coincident with that of adenosine A1 receptors in vitro, reported previously, but discretely different from that of rCBF. Conclusion: 11 C" @default.
• W2183639023 created "2016-06-24" @default.
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• W2183639023 date "2005-01-01" @default.
• W2183639023 modified "2023-09-22" @default.
• W2183639023 title "Adenosine A 1 Receptor Mapping of the Human" @default.
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