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- W2183639795 abstract "Increasing evidence indicates that microRNAs (miRNAs) play a critical role in the pathogenesis of inflammatory diseases. Oral lichen planus (OLP) is a chroni c inflammatory disease involving the oral mucosal tissues. The role of miRNAs in the pathogenesis of OLP has not been investigated. Therefore, the aim of this study was to investigate the expression levels of miRNA - 21 and miRNA - 146a in oral tissue samples from patients with OLP and matched healthy controls using real - time quantitative reverse transcriptase polymerase chain reaction (qRT - PCR). Our results showed a significant over - expression of miRNA - 21( 3 .2 - fold) and miRNA - 146a (5.6 - fold) in OLP patients com pared to healthy controls. These results indicate that miRNAs may be the novel candidate biomarkers for the implication of miRNAs in the pathogenesis of OLP. (Gihane Gharib Madkour, Hani EL Nahass, Wesam Abd El Moneim Mohamad. Expression levels of microRNA - 21 and microRNA - 146a in patients with Oral Lichen Planus. Life Sci J 2012;9( 4 ): 466 6 - 467 0 ) (ISSN:1097 - 8135). http://www.lifesciencesite.com .. 703" @default.
- W2183639795 created "2016-06-24" @default.
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- W2183639795 date "2012-01-01" @default.
- W2183639795 modified "2023-09-27" @default.
- W2183639795 title "Expression levels of microRNA - 21 and microRNA - 146a in patients with Oral Lichen Planus" @default.
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