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- W2183640341 abstract "Infection with Helicobacter pylori (H. pylori) in addition to inflammation in gastric mucosa and much mortality may progress to gastric cancer. Gastric cancers like many other cancers have a multistage process and cause obvious changes in environmental, genetic and epigenetic factors. Polymorphism in promoter region of CDH1 gene has been associated with reduced E-cadherin protein expression. It has been proposed that H. pylori infection may cause multiple nucleotide changes in CDH1 gene. Aimed: We evaluated the association between -160 (C>A) CDH1 gene polymorphism with H. pylori infection in Kurdish population. Methods: A total of 162 biopsies taken from non-ulcer dyspepsia patients were classified as H.pylori infected and H.pylori uninfected. All previous diagnoses confirmed pathologically and molecularly. Polymorphism in -160(C>A) CDH1 was evaluated by PCR- RFLP. Results: Infection with H. pylori was found in 67% of patients. H. pylori infection was more frequently found in biopsies with the -160C/A genotype than those with the -160C/C (P value = 0.01). Conclusion: 160C/A genotype might require H. pylori infection to promote the inactivation of CDH1. This suggests that H. pylori infection might affect gastric cancer (GC) in an initial stage. (Abbas Ahmadi, Farid Zandi, Alireza Gharib, Neda Menbari, Javad Hosseini, Mohammad Abdi, Akbar Jalili, Mohammad Nazir Menbari, Relationship Between Polymorphism in Promoter Region of E-Cadherin (Cdh1) Gene and Helicobacter Pylori Infection in Kurdish Population of Iran. Life Sci J 2013;10(12s): 552-556) (ISSN:1097-8135). http://www.lifesciencesite.com. 90" @default.
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- W2183640341 date "2013-01-01" @default.
- W2183640341 modified "2023-09-26" @default.
- W2183640341 title "Relationship Between Polymorphism in Promoter Region of E-Cadherin (Cdh1) Gene and Helicobacter Pylori Infection in Kurdish Population of Iran" @default.
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