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- W2183640728 abstract "BACKGROUND: Inflammatory bowel disease (IBD) is a common disease in hu - man resulted from a various of factors including genetic background, immune system and envi - ronment factors. OBJECTIVES: Recent studies suggest pro-in - flammatory cytokine IL-17 producing cell subset was involved in the disease development and the maintenance of IBD. And the differentiated and activation of IL-17 producing cells were mostly dependent on the cytokines profile secreted by innate cells in intestinal tissues. In this study, we examined the functions of IL-6 signal in regultory of IL-17 production in acute IBD model. MATERIALS AND METHODS: Wildtype mice were treated with anti-IL-6 neutralizing antibodies to block IL-6 signal And then treated with DSS to induce acute IBD. RESULTS: Mice treated with anti-IL-6 neutraliz - ing antibodies show severe colitis and high level of pro-inflammatory cytokine IL-17 production in DSS-induced acute IBD model when conpared with control group. Our research suggested blockade of IL-6 signal pathways in acute colitus model resulted in specifical activation of IL-17 producing cell population. Furthermore, CD44+ activated Th17 cell popualtion and CD44- IL-17 producing T cells exhibited different susceptibili - ty to IL-6 signal in our model. CONCLUSIONS: Blockade of IL-6 signal in DSS-induced acuted IBD model increased IL-17 production level specifically in CD44- T cells and reduced CD44+ Th17 cell population." @default.
- W2183640728 created "2016-06-24" @default.
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- W2183640728 date "2013-01-01" @default.
- W2183640728 modified "2023-09-24" @default.
- W2183640728 title "BlockadeofIL-6signalexacerbatesacute inflammatoryboweldiseaseviainhibitingIL-17 producinginactivatedCD4+Th17population" @default.
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