Matches in SemOpenAlex for { <https://semopenalex.org/work/W2183645018> ?p ?o ?g. }
- W2183645018 abstract "Macrophages play a pivotal role in tissue fibrogenesis, which underlies the pathogenesis of many end-stage chronic inflammatory diseases. MicroRNAs are key regulators of immune cell functions, but their roles in macrophage's fibrogenesis have not been characterized. Here we show that IL-4 and IL-13 induce miR-142-5p and downregulate miR-130a-3p in macrophages; these changes sustain the profibrogenic effect of macrophages. In vitro, miR-142-5p mimic prolongs STAT6 phosphorylation by targeting its negative regulator, SOCS1. Blocking miR-130a relieves its inhibition of PPARγ, which coordinates STAT6 signalling. In vivo, inhibiting miR-142-5p and increasing miR-130a-3p expression with locked nucleic acid-modified oligonucleotides inhibits CCL4-induced liver fibrosis and bleomycin-induced lung fibrosis in mice. Furthermore, macrophages from the tissue samples of patients with liver cirrhosis and idiopathic pulmonary fibrosis display increased miR-142-5p and decreased miR-130a-3p expression. Therefore, miR-142-5p and miR-130a-3p regulate macrophage profibrogenic gene expression in chronic inflammation." @default.
- W2183645018 created "2016-06-24" @default.
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- W2183645018 date "2015-10-05" @default.
- W2183645018 modified "2023-10-11" @default.
- W2183645018 title "miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program" @default.
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- W2183645018 doi "https://doi.org/10.1038/ncomms9523" @default.
- W2183645018 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4600756" @default.
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