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- W2183645809 abstract "SUMMARY Twopatients withHerpesvirus hominis (herpes simplex) encephalitis were investigated byserial isotope encephalograms using technetium-99m pertechnetate. Inthefirst casethediagnosis was madebybrain biopsy, andbysuccessful tissue culture, andwas confirmed bya significant rise inantibody titre, butinthesecond thelaboratory evidence was exclusively serological. Necrotizing encephalitis was presumed inbothcasesbecause theillness was graveandfocal signs developed in conjunction withradiological andelectroencephalographic evidence ofcircumscribed lesions ofthe hemisphere. Theemergenceofnew lesions inthebrain scanatatimeofclinical remission was found tobeawarning ofimpending relapse. Suchlesions hadtobedistinguished fromareasofincreasing uptake ofisotope dueonlytolocal change invascular permeability. DecayofEEG activity together withclinical signs offocal abnormality overan areaofisotope concentration indicated anecrotizing lesion. Cytosine arabinoside (cytarabine), an alternative toidoxuridine as an antiviral drug, was usedinbothcases.A third patient, suspected inlife ofhaving a degenerative encephalopathy, was foundatnecropsytohavenecrotizing encephalitis. Herpes infection though probable was notconfirmed. Themostseverelesions were inthefrontal andtemporal lobes, whichhadshownincreased uptake oftechnetium intheencephalogram performed sixweeksbefore herdeath. For30years, since Herpes simplex wasfirst isolated fromthebrain ofadying child (Smith, Lennette, andReames, 1941), thevirus hasbeen knownforits sporadic butvirulent neurotropism. Occasionally giving rise toafulminating infec" @default.
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- W2183645809 date "1972-01-01" @default.
- W2183645809 modified "2023-09-27" @default.
- W2183645809 title "Isotope encephalography inthemanagement of acuteherpesvirus encephalitis" @default.
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