FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2183652160> ?p ?o ?g. }

• W2183652160 endingPage "F658" @default.
• W2183652160 startingPage "F650" @default.
• W2183652160 abstract "Serotonin (5-HT) stimulates mitogenesis in rat renal mesangial cells through a G protein-coupled 5-HT(2A) receptor. We tested the hypothesis that oxidants might be involved in the signal transduction pathway linking the receptor to extracellular signal-regulated protein kinase (ERK). 5-HT rapidly increased the activity and phosphorylation of ERK. These effects were blocked by the 5-HT(2A) receptor antagonist ketanserin. The peak effect was noted at 5-10 min, and half-maximal stimulation was achieved at 10-30 nM 5-HT. Chemical inhibitor and activator studies supported the involvement of phospholipase C, protein kinase C (PKC), and reactive oxygen species (ROS, i.e., H(2)O(2) and superoxide) generated by an NAD(P)H oxidase-like enzyme in the ERK activation cascade. Mapping studies supported a location for the NAD(P)H oxidase enzyme and the ROS downstream from PKC. Our studies are most consistent with an ERK activation pathway as follows: 5-HT(2A) receptor --> G(q) protein --> phospholipase C --> diacylglycerol --> classical PKC --> NAD(P)H oxidase --> superoxide --> superoxide dismutase --> H(2)O(2) --> mitogen-activated extracellular signal-regulated kinase --> ERK. These studies demonstrate a role for the 5-HT(2A) receptor in rapid, potent, and efficacious activation of ERK in rat renal mesangial cells. They support a role for oxidants in conveying the stimulatory signal from 5-HT, because 1) chemical antioxidants attenuate the 5-HT signal, 2) oxidants and 5-HT selectively activate ERK to a similar degree, 3) 5-HT produces superoxide and H(2)O(2) in these cells, and 4) a specific enzyme [NAD(P)H oxidase] has been implicated as the source of the ROS, which react selectively downstream of classical PKC." @default.
• W2183652160 created "2016-06-24" @default.
• W2183652160 creator A5016589874 @default.
• W2183652160 creator A5033763744 @default.
• W2183652160 creator A5037713958 @default.
• W2183652160 creator A5046634274 @default.
• W2183652160 creator A5056935796 @default.
• W2183652160 creator A5066348101 @default.
• W2183652160 creator A5066493268 @default.
• W2183652160 creator A5066605794 @default.
• W2183652160 creator A5070798800 @default.
• W2183652160 creator A5077156572 @default.
• W2183652160 date "2000-04-01" @default.
• W2183652160 modified "2023-09-26" @default.
• W2183652160 title "5-HT_2Areceptors stimulate mitogen-activated protein kinase via H₂O₂generation in rat renal mesangial cells" @default.
• W2183652160 cites W1535828429 @default.
• W2183652160 cites W1558113022 @default.
• W2183652160 cites W1563653502 @default.
• W2183652160 cites W1651282701 @default.
• W2183652160 cites W1759706356 @default.
• W2183652160 cites W1786911182 @default.
• W2183652160 cites W1838300529 @default.
• W2183652160 cites W1897680432 @default.
• W2183652160 cites W1965696818 @default.
• W2183652160 cites W1973665038 @default.
• W2183652160 cites W1976555160 @default.
• W2183652160 cites W1987790381 @default.
• W2183652160 cites W1994187352 @default.
• W2183652160 cites W2004283265 @default.
• W2183652160 cites W2006008851 @default.
• W2183652160 cites W2008577285 @default.
• W2183652160 cites W2015471917 @default.
• W2183652160 cites W2016331541 @default.
• W2183652160 cites W2020138346 @default.
• W2183652160 cites W2029652412 @default.
• W2183652160 cites W2030585484 @default.
• W2183652160 cites W2048569323 @default.
• W2183652160 cites W2048986390 @default.
• W2183652160 cites W2056531599 @default.
• W2183652160 cites W2059431546 @default.
• W2183652160 cites W2074387820 @default.
• W2183652160 cites W2075012700 @default.
• W2183652160 cites W2086788768 @default.
• W2183652160 cites W2119780153 @default.
• W2183652160 cites W2121904232 @default.
• W2183652160 cites W2126040679 @default.
• W2183652160 cites W2151477904 @default.
• W2183652160 cites W2167800649 @default.
• W2183652160 cites W2184920316 @default.
• W2183652160 cites W2188751783 @default.
• W2183652160 cites W2225309636 @default.
• W2183652160 cites W2284072296 @default.
• W2183652160 cites W2292887731 @default.
• W2183652160 cites W2315467068 @default.
• W2183652160 cites W2337115312 @default.
• W2183652160 cites W2339413510 @default.
• W2183652160 doi "https://doi.org/10.1152/ajprenal.2000.278.4.f650" @default.
• W2183652160 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10751227" @default.
• W2183652160 hasPublicationYear "2000" @default.
• W2183652160 type Work @default.
• W2183652160 sameAs 2183652160 @default.
• W2183652160 citedByCount "82" @default.
• W2183652160 countsByYear W21836521602012 @default.
• W2183652160 countsByYear W21836521602013 @default.
• W2183652160 countsByYear W21836521602014 @default.
• W2183652160 countsByYear W21836521602015 @default.
• W2183652160 countsByYear W21836521602016 @default.
• W2183652160 countsByYear W21836521602017 @default.
• W2183652160 countsByYear W21836521602018 @default.
• W2183652160 countsByYear W21836521602019 @default.
• W2183652160 countsByYear W21836521602020 @default.
• W2183652160 countsByYear W21836521602021 @default.
• W2183652160 countsByYear W21836521602022 @default.
• W2183652160 countsByYear W21836521602023 @default.
• W2183652160 crossrefType "journal-article" @default.
• W2183652160 hasAuthorship W2183652160A5016589874 @default.
• W2183652160 hasAuthorship W2183652160A5033763744 @default.
• W2183652160 hasAuthorship W2183652160A5037713958 @default.
• W2183652160 hasAuthorship W2183652160A5046634274 @default.
• W2183652160 hasAuthorship W2183652160A5056935796 @default.
• W2183652160 hasAuthorship W2183652160A5066348101 @default.
• W2183652160 hasAuthorship W2183652160A5066493268 @default.
• W2183652160 hasAuthorship W2183652160A5066605794 @default.
• W2183652160 hasAuthorship W2183652160A5070798800 @default.
• W2183652160 hasAuthorship W2183652160A5077156572 @default.
• W2183652160 hasConcept C153911025 @default.
• W2183652160 hasConcept C170493617 @default.
• W2183652160 hasConcept C181199279 @default.
• W2183652160 hasConcept C184235292 @default.
• W2183652160 hasConcept C185592680 @default.
• W2183652160 hasConcept C195794163 @default.
• W2183652160 hasConcept C202751555 @default.
• W2183652160 hasConcept C2778597717 @default.
• W2183652160 hasConcept C2779131090 @default.
• W2183652160 hasConcept C2779719074 @default.
• W2183652160 hasConcept C2780795997 @default.
• W2183652160 hasConcept C2781252958 @default.
• W2183652160 hasConcept C48349386 @default.

• next