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- W2183654354 abstract "To help prescribers of warfarin reach the therapeutic International Normalized Ratio as quickly and safely as possible, dosing nomograms for this medication have been established in institutions throughout the U.S. However, even when warfarin is administered using a well-designed nomogram, it is helpful to understand some of the pharmacokinetic and pharmacodynamic idiosyncrasies inherent to this agent with its narrow therapeutic window. This article discusses (1) the plasma half-lives of both warfarin and the clotting proteins that it inhibits; (2) warfarin’s paradoxical procoagulant effect early in therapy; (3) the ways in which age, diseases, drugs, and nutritional conditions affect the patient’s response to warfarin acutely and chronically; and (4) the benefits and the risks of loading-dose regimens." @default.
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- W2183654354 date "2004-10-01" @default.
- W2183654354 modified "2023-09-25" @default.
- W2183654354 title "Optimal understanding of warfarin: Beyond the nomogram" @default.
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