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- W2183655057 abstract "Background: Malaria is a major public health problem in Sub-Saharan Africa today and it is increasingly burdensome to treat the infection. First line therapy includes the use of artesunate and amodiaquine medications. Previous studies have supported and encouraged the manufacture of a once daily drug dosing for better compliance. Others studies argue and support a twice daily approach as a more effective therapy. Objectives: The study aimed to determine the appropriate time to administer the second dose of artesunate tablets and to define its optimum dosage regimen (once or twice daily) in mono and combination therapy with amodiaquine. Methods: Samples were collected at baseline, and then 0.08h,0.17h,0.25h,0.5h,1.5h,3h,5h,12h and 24h after a single dose of artesunate (200 mg) from 16 healthy male volunteers. Peak concentration of total dihydroartemisinin was achieved within 0.71h±0.36, 1.20h±0.28, 1.35h±0.06 for monotherapy, fixed combination and non-fixed combination respectively. The elimination half lives were th 0.96h±0.15, 0.98h±0.2 and 0.88h±0.09 respectively. The plasma concentration at the 24 h of single dose administration was found to be 5.33ng/ml±2.6, 6.99ng/ml±3.2 and 6.61ng/ml±2.9 respectively. Results: In all the three formulations employed, the plasma concentration of artesunate after oral, single dose th administration nadirs below the IC50 for Plasmodium falciparum at the 24 hour of sampling. Conclusion: The study reported low incidence of ADRs of severity grades II to IV. The incidence of these ADRs was higher in patients that received d4T-based regimen compared to other regimens." @default.
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- W2183655057 date "2013-01-01" @default.
- W2183655057 modified "2023-09-24" @default.
- W2183655057 title "Plasma drug levels and pharmacokinetics of artesunate after a single dose administration of various combinations with amodiaquine to male volunteers in South Western Nigeria" @default.
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