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• W2183655427 abstract "The chemical composition and pharmacological activity of the dry extract based on the herbal tea composed of black horehound (Ballota nigra) herb, white nettle (Lamium album) herb, wormwood (Artemisiae absinthii) herb in equal amounts have been studied. As a result of the chemical study of the main groups of biologically active substances in the herbal tea and the extract on its basis the presence of phenolic compounds such as derivatives of hydroxycinnamic acid, hydroxycoumarins, flavonoids and their quantitative content have been determined. In the research objects aglycons of flavonoids (luteolin, kaempferol, quercetin, apigenin) have been idenified. 70% ethanol provides a more complete extraction of phenolic compounds from the herbal tea: the content of hydroxycinnamic acid and flavonoids is higher than in the infusion of the herbal tea, it is more than 60% and 80% re spectively; the total amount of phenolic compounds in the dry extract is greater than in the infusion – more than 10% (calculated with reference to a dry residue). The results of the pharmacological research suggest the presence of the sedative effect of the dry extract from the herbal tea in the dose of 400 mg/kg. The dry extract from the herbal tea exhibits the antihypoxic activity that exceeds the activity of Piracetam, thus proving its cerebroprotective action. In the last decades diseases associated with the human higher nervous dysfunctions remain one of the most important medical and social problems of most countries in the world, first of all, due to high prevalence and severe consequences for public health. According to the World Health Organization (WHO), approximately 6.7 mln. people die from cerebrovascular diseases annually in the world. Insult is the second most common cause of death; 6150000 inhabitants of the Earth (92 per 100 000) died from insult in 2008, i.e. 10.8% of the total mortality. In Ukraine 754 461 patients died in 2008: of them from insult – 42 422 (91.8 per 100 000 of the population, 5.6% of all the dead) [9, 10, 12]. For the treatment of cerebrovascular diseases, in which pathogenesis hypoxia is of key importance, medicines of various groups are used: nootropic (piracetam), amino acid and peptidergic, acetylcholinergic (donepezil, galantamine, rivastigmine), glutamatergic; when using them a number of side effects appears. The use of herbal drugs in patients with cerebrovascular disease is one of the alternative therapies accelerating normalization of the functions of the nervous system [11]. Therefore, development of effective herbal medicines in cerebrovascular diseases is an important task. The aim of the work was to study the chemical composition, identify the effects on behavioural responses and the possible antihypoxic activity of the herbal tea and the dry extract on its basis." @default.
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• W2183655427 date "2014-12-01" @default.
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• W2183655427 title "The study of the chemical composition, effects on behavioural responses and the antihypoxic activity of the herbal tea and the dry extract on its basis" @default.
• W2183655427 doi "https://doi.org/10.24959/nphj.14.2020" @default.
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