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- W2183659680 abstract "With the current publication from the FDA on the guidance of metabolites in safety testing (MIST), there is added emphasis on the need to have adequate LC/MS platforms to be able to accommodate these new challenges. In order to address these challenges, we present an LC/MS workflow that consists of a modified QTof mass spectrometer with enhanced dynamic range and improved spectral resolution (Figure 2). The improved dynamic range is achieved via a novel ADC based detection system which allows us to obtain a dynamic range of over 10. The enhanced spectral resolution of over 40,000 FWHM is achieved using a folded oa-ToF geometry with high field extraction and multiple dual stage and single stage reflectrons. A MODIFIED QTOF MASS SPECTROMETER FOR RAPID AND UNEQUIVOCAL IDENTIFICATION OF METABOLITES IN-VIVO WITH ENHANCED MASS SPECTRAL RESOLUTION AND DYNAMIC RANGE" @default.
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- W2183659680 date "2009-01-01" @default.
- W2183659680 modified "2023-10-18" @default.
- W2183659680 title "A MODIFIED QTOF MASS SPECTROMETER FOR RAPID AND UNEQUIVOCAL IDENTIFICATION OF METABOLITES IN-VIVO WITH ENHANCED MASS SPECTRAL RESOLUTION AND DYNAMIC RANGE" @default.
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