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- W2183660186 abstract "We have developed a double-stranded locked nucleic acid (dsLNA) probe for monitoring the intracellular gene expression toward the investigation of the role of mechanical injury in cancer metastasis. Specifically, the dsLNA probe is shown to allow real-time detection of intracellular mRNA in living cells. Using the dsLNA probes, the spatiotemporal gene expressions of cancer cells after mechanical injury are monitored for days. We show that the release of contact inhibition is sufficient to induce the migratory behavior of cancer cells while mechanical injury triggers the cellular antioxidant response in a region ~100 µm away from the wound." @default.
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- W2183660186 date "2011-12-01" @default.
- W2183660186 modified "2023-09-26" @default.
- W2183660186 title "Double-stranded locked nucleic acid probes for revealing intracellular gene expression dynamics of cancer cells near mechanical wounds" @default.
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