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• W2183660437 abstract "Blood-brain barrier inhibits most of drugs and genetic materials from reaching the brain. So, developing high efficiency carriers for gene and drug delivery to the brain, is the challenging area in pharmaceutical sciences. This investigation aimed to target DNA to brain using Serine-Arginine-Leucine (SRL) functionalized PAMAM dendrimers as a novel gene delivery system. The SRL peptide was linked on G4 PAMAM dendrimers using bifunctional PEG. DNA was then loaded in these functionalized nanoparticles and their physicochemical properties and cellular uptake/distribution evaluated by AFM, NMR, FTIR and fluorescence and confocal microscopy. Also, biodistribution and brain localization of nanoparticles were studied after IV injection of nanoparticles into rat tail. Unmodified nanoparticles were used as control in all evaluations. In vitro studies showed that SRL-modified nanoparticles have good transfection efficacy and low toxicity. Results also showed that SRL is a LRP ligand and SRL-modified nanoparticles internalized by clathrin/caveolin energy-dependent endocytosis to brain capillary endothelial cells. After intravenous administration, the SRL-modified nanoparticles were able to cross the blood-brain barrier and enter the brain parenchyma. Our result showed that, SRL-modified nanoparticles provide a safe and effective nanocarrier for brain gene delivery." @default.
• W2183660437 created "2016-06-24" @default.
• W2183660437 creator A5015800764 @default.
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• W2183660437 creator A5089625720 @default.
• W2183660437 date "2015-10-01" @default.
• W2183660437 modified "2023-10-13" @default.
• W2183660437 title "Synthesis and characterization of a PAMAM dendrimer nanocarrier functionalized by SRL peptide for targeted gene delivery to the brain" @default.
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• W2183660437 doi "https://doi.org/10.1016/j.ejps.2015.06.024" @default.
• W2183660437 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26118442" @default.
• W2183660437 hasPublicationYear "2015" @default.
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