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• W2183660614 abstract "4 Abstract: BACKGROUND: Superficial and subcutaneous mycoses have a high prevalence and, often, chronic evolu- tion. Therefore, they need extensive treatment with topic and/or systemic antifungal agents. Azoles and ali- lamines (terbinafine) are first-choice drugs to treat human and animal infections. Thus, evaluation of the effica- cy of these drugs is important for a successful treatment. However, there are few studies that evaluate the in vitro activity of antifungal agents. OBJECTIVE - To evaluate the in vitro efficacy of terbinafine activity against filamentous fungi and yeasts that cause mycoses. METHOD - The in vitro activity of terbinafine (0.125-100μg) against 10 fungi species was evaluated by the disk-dif- fusion and microdilution/reference methods to determine the Minimum Inhibitory Concentration (MIC). RESULTS - We found a high susceptibility to terbinafine in: T. rubrum, M. gypseum, T. mentagrophytes, T. ton- surans, M. canis, C. carrionii and E. floccosum (halo ≥ 40mm with 0.125μg disk). S. hyalinum and C. parapsilo- sis were considered susceptible, but less than the others. Fusarium spp. showed the lowest susceptibility (halo=12mm with 2μg disk; MIC 8μg/mL). CONCLUSIONS - The results of this research confirm previous findings about the efficacy of terbinafine. The drug was shown to be highly effective to treat dermatophyte infections. The disk-diffusion method was easy to use and is a suitable technique for routine use in clinical laboratories. Keywords: Antifungal agents; Arthrodermataceae; Fungi; Mycosis Resumo: FUNDAMENTOS: As micoses superficiais e subcutâneas tem alta prevalencia e, muitas vezes, carater croni- co, necessitando tratamentos topicos e/ou sistemicos com antifungicos. As drogas de escolha sao azois e alila- minas (terbinafina). E necessario avaliar a eficacia das drogas para tratamento em humanos e em animais. Estudos para avaliar in vitro a acao dos antimicoticos sao raros, especialmente, contra fungos filamentosos. OBJETIVO - Avaliar a eficacia in vitro da terbinafina pelo metodo de disco-difusao contra fungos filamentosos e le- veduras agentes de micoses." @default.
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• W2183660614 date "2010-01-01" @default.
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• W2183660614 title "Evaluation of the disk-diffusion method to determine the in vitro efficacy of terbinafine against subcutaneous and superficial mycoses agents Avaliação do método de disco-difusão para determinação da eficácia da terbinafina in vitro em agentes de micoses superficiais e subcutâneas*" @default.
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