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- W2183665817 abstract "Cardiovascular disease (CVD) has remained a leading cause of death worldwide for the past several decades. It is a progressive pathological condition which gradually develops during the course of one’s life at a rate which depends on the extent of interplay between its unmodifiable and modifiable risk factors. Its genesis lies in the initiation of atherosclerosis, which may remain asymptomatic in the subclinical state. Its gradual progression culminates in symptomatic CVD and its onset invariably predicts an adverse prognosis leading to multiple recurrent cardiac upheavals if uncontrolled. At this stage, clinicians largely rely on routine diagnostic procedures and physical examination for arriving at therapeutic decisions on patient management. Such evaluations are however bound by limitations, especially with irreversible changes having already set in at molecular and cellular levels, thus largely leading to ineffective treatment. Logically, disease management can be considered successful if undertaken before the onset of overt clinical manifestations which may conclusively require presymptomatic prognostication of the pathological condition. Biomarkers, in this regard, are gaining increasing interest, as they are, to some extent able to identify high risk subjects and predict the future development of CVD in them. Further, it is also interesting to note that ethnicity plays a very important role in determining the extent to which these markers can be implicated in cardiovascular risk prediction in specific populations. This is particularly true in case of Asian Indian populations wherein biomarkers, established for the Western population, are not so significant and certain other markers which are considered of low priority in Caucasians assume significance. This review focuses on different biochemical and immunological parameters, some of which have already been well established as biomarkers and routinely considered by clinicians for risk assessment. Certain additional novel parameters, which are slowly gaining importance as disease causal and consequential agents and throwing throw light on the progress of the disease are also highlighted." @default.
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- W2183665817 date "2014-01-01" @default.
- W2183665817 modified "2023-09-27" @default.
- W2183665817 title "A Review of Conventional and Emerging Biomarkers for Prognostication of Cardiovascular Disease." @default.
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