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• W2183667303 abstract "Campylobacter jejuni, the leading cause of human bacterial gastroenteritis, requires low environmental oxygen and high carbon dioxide for optimum growth, but the molecular basis for the carbon dioxide requirement is unclear. One factor may be inefficient conversion of gaseous CO2 to bicarbonate, the required substrate of various carboxylases. Two putative carbonic anhydrases (CAs) are encoded in the genome of C. jejuni strain NCTC 11168 (Cj0229 and Cj0237). Here, we show that the deletion of the cj0237 (canB) gene alone prevents growth in complex media at low (1% v/v) CO2 and significantly reduces the growth rate at high (5% v/v) CO2. In minimal media incubated under high CO2, the canB mutant grew on L-aspartate but not on the key C3 compounds L-serine, pyruvate and L-lactate, showing that CanB is crucial in bicarbonate provision for pyruvate carboxylase-mediated oxaloacetate synthesis. Nevertheless, purified CanB (a dimeric, anion and acetazolamide sensitive, zinc-containing type II beta-class enzyme) hydrates CO2 actively only above pH 8 and with a high Km (∼ 34 mM). At typical cytoplasmic pH values and low CO2, these kinetic properties might limit intracellular bicarbonate availability. Taken together, our data suggest CanB is a major contributor to the capnophilic growth phenotype of C. jejuni." @default.
• W2183667303 created "2016-06-24" @default.
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• W2183667303 date "2015-12-21" @default.
• W2183667303 modified "2023-10-16" @default.
• W2183667303 title "Major contribution of the type <scp>II</scp> beta carbonic anhydrase <scp>CanB</scp> (<scp>C</scp>j0237) to the capnophilic growth phenotype of <scp><i>C</i></scp><i>ampylobacter jejuni</i>" @default.
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• W2183667303 doi "https://doi.org/10.1111/1462-2920.13092" @default.
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