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• W2183670999 abstract "In recent years autologous stem cell transplantation has been increasingly used in haematological disorders. CD34+ progenitor cell counts and haematopoietic clonogenic potential have been widely studied as laboratory parameters capable of predicting engraftment following myeloablative treatment. However, factors predicting successful stem cell mobilisation and engraftment are widely discussed. The aims of this study were: 1) to evaluate which CD34+ cell subsets contained in leucapheresis products could be regarded as the most predictive of longterm haematopoietic recovery after autologous peripheral blood stem cell transplantation (auto-PBSCT), and 2) to identify clinical and biological factors predicting successful mobilisation. To reach the first goal, in a restricted group of 34 patients the total amounts of CD34+ cells and CD34+ cell subsets, defined by the expression of CD123 (a subunit of IL-3/R), CD133 (AC133), HLA-DR, CD38, CD117 (c-kit/R), and CD90 (Thy-1) antigens, were correlated with the numbers of short-term (i.e. colony forming cells-CFC) and long-term culture-CFC (LTCCFC) (generated at the 5 th week of culture), and with the kinetics of haematopoietic engraftment following autoPBSCT. Our data demonstrated that some of the most primitive progenitor subsets (CD34+/CD117-/HLA-DR-, and CD34+/CD38+/HLA-DR-) showed the strongest correlation with LTC-CFC numbers generated within the Part of this paper has been presented at the Meeting of Clinical Pathology and Transfusion Medicine, held at" @default.
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• W2183670999 date "2003-01-01" @default.
• W2183670999 modified "2023-09-26" @default.
• W2183670999 title "Evaluation of clinical and biological parameters useful for predicting the extent of progenitor cell mobilisation and long- term engraftment in transplanted onco-haematological patients" @default.
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