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• W2183672987 abstract "Alveolar macrophages (AM) from smokers contain a much higher quantity of intracellular iron than AM from nonsmokers. Since some forms of iron will catalyze the formation of hydroxyl radical ( *OH) from superoxide and hydrogen peroxide, the ability ofAM derived from smokers and nonsmokers to generate *OH was assessed. No detectable *OH was produced by AM from either source, suggesting that iron sequestration byAM may limit the potential for * OH-mediated lung injury. Consistent with this hypothesis, the ability of bronchoalveolar lavage fluid (BAL) from smokers and nonsmokers to act as an *OH catalyst decreased after exposure to AM.We found that, like AM, human monocyte-derived macrophages (MDM) have the ability to acquire large quantities of iron from small low molecular weight iron chelates as well as decrease the ability ofBAL to act as a *OH catalyst. WhenMDM orAM were exposed to the iron chelates or BAL they were then able to generate OH after phorbol myristate acetate stimulation. However, when acutely iron-loaded or BAL-exposed MDM were placed in culture, their ability to produce *OH decreased with time to the level of non-iron-exposed controls. This process correlated with iron translocation from the plasma membrane to the cytosol as well as a 3-9-fold increase in cellular ferritin. No increase in antioxidant enzyme levels or induction of the heat shock response was observed. Iron sequestration by" @default.
• W2183672987 created "2016-06-24" @default.
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• W2183672987 date "1993-01-01" @default.
• W2183672987 modified "2023-09-26" @default.
• W2183672987 title "Potential for Extracellular Hydroxyl Radical Formation" @default.
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