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- W2183673209 abstract "Summary The analgesic activity of the leaves of methanolic extract of Drymaria cordata Willd (Caryophyllaceae) was investigated by non-narcotic models like acetic acid induced writhing syndrome test and narcotic models like hot plate, and tail flick models. Pretreatment with oral doses of 300, 600 and 900mg/kg body wt revealed significant (P<0.01) analgesic activity in acetic acid induced writhing syndrome as compared to the vehicle treated control group. However in narcotic models, the effect was not significant. The preliminary phytochemical investigation revealed the presence of glycosides, tannins, diterpenes, alkaloids and flavonoids, which might be responsible for its analgesic effect. From the above study, it can be concluded that analgesic activity of Drymaria cordata methanolic extract (DCME) might due to some of these constituents present therein and that the plant might have exerted its analgesic action by peripheral mechanism as evidenced by its significant analgesic effect on acetic acid induced writhing syndrome and little or no effect on hot plate or tail flick method. Further study on its mechanism of action and fractionation of active constituents may establish the preliminary finding." @default.
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- W2183673209 date "2009-01-01" @default.
- W2183673209 modified "2023-09-26" @default.
- W2183673209 title "DRYMARIA CORDATA WILLD CARYOPHYLLACEAE" @default.
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