Matches in SemOpenAlex for { <https://semopenalex.org/work/W2183674489> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2183674489 endingPage "F85" @default.
- W2183674489 startingPage "F75" @default.
- W2183674489 abstract "Renal ischemia causes redistribution of Na(+)-K(+)-adenosinetriphosphatase (Na(+)-K(+)-ATPase) to the apical membrane of proximal tubules. We determined the time course of regeneration of Na(+)-K(+)-ATPase polarity and sought evidence of increased enzyme production during recovery as a means to restore polarity. Anesthetized rats underwent 45 min renal ischemia and reflow of 15 min, 2 h, 6 h, and 24 h. Immunofluorescent and electron microscopy showed loss of strict basolateral localization of Na(+)-K(+)-ATPase at 15 min reflow with repolarization by 24 h in sublethally injured cells. Both alpha 1- and beta-subunits were only in microsomal fractions at all reflow intervals. Immunodetectable levels of both subunits declined to 60-70% of control by 24 h reflow. Levels of mRNA for each subunit declined in parallel through 24 h to 55% of control. Overall transcription was profoundly depressed through 6 h but had recovered to near control by 24 h. Specific transcription of alpha 1- and beta-subunit mRNA was markedly decreased after ischemia and only partially recovered by 24 h. These results suggest that recycling of misplaced units rather than new Na(+)-K(+)-ATPase production is the means by which renal epithelia initially repolarize after ischemic injury." @default.
- W2183674489 created "2016-06-24" @default.
- W2183674489 creator A5031476322 @default.
- W2183674489 creator A5045989293 @default.
- W2183674489 creator A5063643118 @default.
- W2183674489 creator A5070406524 @default.
- W2183674489 creator A5082597667 @default.
- W2183674489 date "1994-07-01" @default.
- W2183674489 modified "2023-09-25" @default.
- W2183674489 title "Expression and molecular regulation of Na(+)-K(+)-ATPase after renal ischemia" @default.
- W2183674489 doi "https://doi.org/10.1152/ajprenal.1994.267.1.f75" @default.
- W2183674489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8048568" @default.
- W2183674489 hasPublicationYear "1994" @default.
- W2183674489 type Work @default.
- W2183674489 sameAs 2183674489 @default.
- W2183674489 citedByCount "26" @default.
- W2183674489 countsByYear W21836744892015 @default.
- W2183674489 countsByYear W21836744892016 @default.
- W2183674489 countsByYear W21836744892017 @default.
- W2183674489 countsByYear W21836744892020 @default.
- W2183674489 countsByYear W21836744892021 @default.
- W2183674489 countsByYear W21836744892023 @default.
- W2183674489 crossrefType "journal-article" @default.
- W2183674489 hasAuthorship W2183674489A5031476322 @default.
- W2183674489 hasAuthorship W2183674489A5045989293 @default.
- W2183674489 hasAuthorship W2183674489A5063643118 @default.
- W2183674489 hasAuthorship W2183674489A5070406524 @default.
- W2183674489 hasAuthorship W2183674489A5082597667 @default.
- W2183674489 hasConcept C104292427 @default.
- W2183674489 hasConcept C104317684 @default.
- W2183674489 hasConcept C105580179 @default.
- W2183674489 hasConcept C126322002 @default.
- W2183674489 hasConcept C134018914 @default.
- W2183674489 hasConcept C181199279 @default.
- W2183674489 hasConcept C185592680 @default.
- W2183674489 hasConcept C23265538 @default.
- W2183674489 hasConcept C2780091579 @default.
- W2183674489 hasConcept C2780114680 @default.
- W2183674489 hasConcept C2780721119 @default.
- W2183674489 hasConcept C541997718 @default.
- W2183674489 hasConcept C55493867 @default.
- W2183674489 hasConcept C71924100 @default.
- W2183674489 hasConcept C86803240 @default.
- W2183674489 hasConceptScore W2183674489C104292427 @default.
- W2183674489 hasConceptScore W2183674489C104317684 @default.
- W2183674489 hasConceptScore W2183674489C105580179 @default.
- W2183674489 hasConceptScore W2183674489C126322002 @default.
- W2183674489 hasConceptScore W2183674489C134018914 @default.
- W2183674489 hasConceptScore W2183674489C181199279 @default.
- W2183674489 hasConceptScore W2183674489C185592680 @default.
- W2183674489 hasConceptScore W2183674489C23265538 @default.
- W2183674489 hasConceptScore W2183674489C2780091579 @default.
- W2183674489 hasConceptScore W2183674489C2780114680 @default.
- W2183674489 hasConceptScore W2183674489C2780721119 @default.
- W2183674489 hasConceptScore W2183674489C541997718 @default.
- W2183674489 hasConceptScore W2183674489C55493867 @default.
- W2183674489 hasConceptScore W2183674489C71924100 @default.
- W2183674489 hasConceptScore W2183674489C86803240 @default.
- W2183674489 hasIssue "1" @default.
- W2183674489 hasLocation W21836744891 @default.
- W2183674489 hasLocation W21836744892 @default.
- W2183674489 hasOpenAccess W2183674489 @default.
- W2183674489 hasPrimaryLocation W21836744891 @default.
- W2183674489 hasRelatedWork W2020959757 @default.
- W2183674489 hasRelatedWork W2042033030 @default.
- W2183674489 hasRelatedWork W2044943066 @default.
- W2183674489 hasRelatedWork W2070511355 @default.
- W2183674489 hasRelatedWork W2082456910 @default.
- W2183674489 hasRelatedWork W2098742882 @default.
- W2183674489 hasRelatedWork W2127085070 @default.
- W2183674489 hasRelatedWork W2127549094 @default.
- W2183674489 hasRelatedWork W2361629841 @default.
- W2183674489 hasRelatedWork W2400445066 @default.
- W2183674489 hasVolume "267" @default.
- W2183674489 isParatext "false" @default.
- W2183674489 isRetracted "false" @default.
- W2183674489 magId "2183674489" @default.
- W2183674489 workType "article" @default.