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- W2183675724 abstract "One of the barriers to more prevalent application of hydrophobic interaction chromatography (HIC) for purification of monoclonal antibodies is that the sample often elutes at salt concentrations which require buffer exchange before the next purification method can be performed. The selectivity provided by HIC is often so powerful that the technique is used despite these limitations, but residual salts constrain process design nevertheless. This report describes a non-salt-based (NSB) binding buffer system that mimics the selectivity of salt-based HIC buffers, but does so at conductivities directly compatible with ion exchange chromatography (IEC). This makes it possible to apply HIC fractions directly to IEC without intermediate buffer exchange, greatly extending the flexibility of HIC with respect to sequential placement in multi-method purification schemes. Results are shown illustrating practical application of the non-salt-based system to multistep purification of monoclonal antibodies." @default.
- W2183675724 created "2016-06-24" @default.
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- W2183675724 date "2000-01-01" @default.
- W2183675724 modified "2023-09-27" @default.
- W2183675724 title "Use of Hydrophobic Interaction Chromatography with a Non-Salt Buffer System for Impr oving Process Economics in Purification of Monoclonal Antibodies" @default.
- W2183675724 hasPublicationYear "2000" @default.
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