Matches in SemOpenAlex for { <https://semopenalex.org/work/W2183677157> ?p ?o ?g. }
- W2183677157 endingPage "C1540" @default.
- W2183677157 startingPage "C1533" @default.
- W2183677157 abstract "The biological characteristics of the globular substance, a precursor of otoconia, are unclear. In the present study, the ATP-induced internal free Ca2+ concentration ([Ca2+]i) changes of the globular substance and the ATP distribution in the vestibular organ were investigated using a Ca2+ indicator, fluo 3, and an adenine nucleotide-specific fluorochrome, quinacrine, by means of confocal laser scanning microscopy. [Ca2+]i showed a rapid and dose-dependent increase in response to ATP with a 50% effective concentration (EC50) of 16.7 microM. This reaction was independent of external Ca2+, indicating the presence of an internal Ca2+ reservoir. Neither adenosine, alpha, beta-methylene-ATP, 3'-O-(4-benzoylbenzoyl)-ATP, ADP, nor UTP evoked this reaction, whereas 2-methylthio-ATP induced an increase of [Ca2+]i with an EC50 of 14.4 microM. Moreover, P2 antagonists, reactive blue 2 and suramin, and a phospholipase C inhibitor, U-73122, inhibited the ATP-induced [Ca2+]i increase. These findings indicate the presence of a P2Y purinoceptor on the globular substance. In addition, granular fluorescence was observed in the quinacrine-stained macular sensory epithelium, indicating the presence of ATP-containing granules in this tissue. These results suggest that a paracrine mechanism involving ATP may exist in the macula and that this mechanism regulates the biological behavior of the globular substance." @default.
- W2183677157 created "2016-06-24" @default.
- W2183677157 creator A5015222308 @default.
- W2183677157 creator A5034517308 @default.
- W2183677157 creator A5068577874 @default.
- W2183677157 creator A5090124204 @default.
- W2183677157 date "1997-11-01" @default.
- W2183677157 modified "2023-09-25" @default.
- W2183677157 title "P2 purinoceptor of the globular substance in the otoconial membrane of the guinea pig inner ear" @default.
- W2183677157 cites W1484271516 @default.
- W2183677157 cites W164399989 @default.
- W2183677157 cites W1920297586 @default.
- W2183677157 cites W1947888345 @default.
- W2183677157 cites W1952385870 @default.
- W2183677157 cites W1963761882 @default.
- W2183677157 cites W1978125566 @default.
- W2183677157 cites W1988131089 @default.
- W2183677157 cites W1997375810 @default.
- W2183677157 cites W2019064616 @default.
- W2183677157 cites W2021527100 @default.
- W2183677157 cites W2021528198 @default.
- W2183677157 cites W2030204779 @default.
- W2183677157 cites W2043453822 @default.
- W2183677157 cites W2053220299 @default.
- W2183677157 cites W2064708775 @default.
- W2183677157 cites W2065009203 @default.
- W2183677157 cites W2070488469 @default.
- W2183677157 cites W2073143611 @default.
- W2183677157 cites W2076530820 @default.
- W2183677157 cites W2077588366 @default.
- W2183677157 cites W2086792418 @default.
- W2183677157 cites W2087971388 @default.
- W2183677157 cites W2088713937 @default.
- W2183677157 cites W2089324198 @default.
- W2183677157 cites W2094446119 @default.
- W2183677157 cites W2121848821 @default.
- W2183677157 cites W2124060652 @default.
- W2183677157 cites W2134991646 @default.
- W2183677157 cites W2161836427 @default.
- W2183677157 cites W2164283705 @default.
- W2183677157 cites W2219416963 @default.
- W2183677157 cites W2395675432 @default.
- W2183677157 doi "https://doi.org/10.1152/ajpcell.1997.273.5.c1533" @default.
- W2183677157 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9374638" @default.
- W2183677157 hasPublicationYear "1997" @default.
- W2183677157 type Work @default.
- W2183677157 sameAs 2183677157 @default.
- W2183677157 citedByCount "13" @default.
- W2183677157 countsByYear W21836771572012 @default.
- W2183677157 countsByYear W21836771572021 @default.
- W2183677157 crossrefType "journal-article" @default.
- W2183677157 hasAuthorship W2183677157A5015222308 @default.
- W2183677157 hasAuthorship W2183677157A5034517308 @default.
- W2183677157 hasAuthorship W2183677157A5068577874 @default.
- W2183677157 hasAuthorship W2183677157A5090124204 @default.
- W2183677157 hasConcept C118303440 @default.
- W2183677157 hasConcept C12554922 @default.
- W2183677157 hasConcept C134018914 @default.
- W2183677157 hasConcept C170493617 @default.
- W2183677157 hasConcept C181199279 @default.
- W2183677157 hasConcept C185592680 @default.
- W2183677157 hasConcept C202751555 @default.
- W2183677157 hasConcept C2776182878 @default.
- W2183677157 hasConcept C2776533618 @default.
- W2183677157 hasConcept C2776991684 @default.
- W2183677157 hasConcept C2778597717 @default.
- W2183677157 hasConcept C2778815084 @default.
- W2183677157 hasConcept C2779564974 @default.
- W2183677157 hasConcept C55493867 @default.
- W2183677157 hasConcept C57306754 @default.
- W2183677157 hasConcept C86803240 @default.
- W2183677157 hasConceptScore W2183677157C118303440 @default.
- W2183677157 hasConceptScore W2183677157C12554922 @default.
- W2183677157 hasConceptScore W2183677157C134018914 @default.
- W2183677157 hasConceptScore W2183677157C170493617 @default.
- W2183677157 hasConceptScore W2183677157C181199279 @default.
- W2183677157 hasConceptScore W2183677157C185592680 @default.
- W2183677157 hasConceptScore W2183677157C202751555 @default.
- W2183677157 hasConceptScore W2183677157C2776182878 @default.
- W2183677157 hasConceptScore W2183677157C2776533618 @default.
- W2183677157 hasConceptScore W2183677157C2776991684 @default.
- W2183677157 hasConceptScore W2183677157C2778597717 @default.
- W2183677157 hasConceptScore W2183677157C2778815084 @default.
- W2183677157 hasConceptScore W2183677157C2779564974 @default.
- W2183677157 hasConceptScore W2183677157C55493867 @default.
- W2183677157 hasConceptScore W2183677157C57306754 @default.
- W2183677157 hasConceptScore W2183677157C86803240 @default.
- W2183677157 hasIssue "5" @default.
- W2183677157 hasLocation W21836771571 @default.
- W2183677157 hasLocation W21836771572 @default.
- W2183677157 hasOpenAccess W2183677157 @default.
- W2183677157 hasPrimaryLocation W21836771571 @default.
- W2183677157 hasRelatedWork W1987466502 @default.
- W2183677157 hasRelatedWork W2000937353 @default.
- W2183677157 hasRelatedWork W2027509148 @default.
- W2183677157 hasRelatedWork W2029617756 @default.
- W2183677157 hasRelatedWork W2035817876 @default.
- W2183677157 hasRelatedWork W2049845583 @default.