FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2183685355> ?p ?o ?g. }

• W2183685355 endingPage "624" @default.
• W2183685355 startingPage "619" @default.
• W2183685355 abstract "Glutathione S-transferase (GST) enzyme activity, GST isoenzyme composition and glutathione (GSH) concentration were assessed in normal and squamous cell carcinoma specimens of 14 patients with oral or oropharyngeal cancer and 11 patients with laryngeal cancer. Comparing malignant with normal oral/oropharyngeal tissues, no significant differences in GSH content, GST enzyme activity or isoenzyme composition were found. However, some tumours had up to 3-fold increased GST enzyme activities and 11 malignant samples over-expressed GST-π GST-πwas present in all normal and malignant oral/oropharyngeal specimens investigated, whereas class a and class μ were detected in only a few samples. GST-μ was present in 28% of the patients with oral/oropharyngeal tumours as compared with ∼60% in the normal population. GST-α, -μ and -π were detected in 91, 64 and 100% of the normal laryngeal tissues respectively. In laryngeal tumours significantly higher levels of GST-π and GSH but significantly lower amounts of GST-α were detected. Levels of class μ GST were generally lower in cancerous tissues, but differences were not significant. In comparison with normal oral/oropharyngeal tissues, normal laryngeal tissues contained almost twice the amount of GST enzyme activity due to higher class α enzyme levels. It is concluded that GST-πis elevated in 11 out of 14 tumours of the oral cavity and values are significantly increased in tumours of the larynx, which may contribute to the inherent anti-cancer drug resistance of these malignancies. In laryngeal tumours the increased GSH levels may confer additional resistance to radiation therapy." @default.
• W2183685355 created "2016-06-24" @default.
• W2183685355 creator A5035708680 @default.
• W2183685355 creator A5038055476 @default.
• W2183685355 creator A5048880494 @default.
• W2183685355 creator A5049461930 @default.
• W2183685355 creator A5053115428 @default.
• W2183685355 date "1995-01-01" @default.
• W2183685355 modified "2023-09-27" @default.
• W2183685355 title "Glutathione S-transferases and glutathione in human head and neck cancer" @default.
• W2183685355 cites W1581414347 @default.
• W2183685355 cites W1599684065 @default.
• W2183685355 cites W1775749144 @default.
• W2183685355 cites W1824883096 @default.
• W2183685355 cites W1953101143 @default.
• W2183685355 cites W1973143173 @default.
• W2183685355 cites W1987437563 @default.
• W2183685355 cites W1988657562 @default.
• W2183685355 cites W2016946201 @default.
• W2183685355 cites W2018050544 @default.
• W2183685355 cites W2019449305 @default.
• W2183685355 cites W2032522259 @default.
• W2183685355 cites W2035989409 @default.
• W2183685355 cites W2037720810 @default.
• W2183685355 cites W2046334666 @default.
• W2183685355 cites W2054457316 @default.
• W2183685355 cites W2057409012 @default.
• W2183685355 cites W2057838215 @default.
• W2183685355 cites W2064035407 @default.
• W2183685355 cites W2064167319 @default.
• W2183685355 cites W2085452515 @default.
• W2183685355 cites W2091572722 @default.
• W2183685355 cites W2097878215 @default.
• W2183685355 cites W2100048938 @default.
• W2183685355 cites W2101119358 @default.
• W2183685355 cites W2118713537 @default.
• W2183685355 cites W2164790099 @default.
• W2183685355 cites W2252382889 @default.
• W2183685355 cites W2412572920 @default.
• W2183685355 cites W2417780620 @default.
• W2183685355 doi "https://doi.org/10.1093/carcin/16.3.619" @default.
• W2183685355 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7697822" @default.
• W2183685355 hasPublicationYear "1995" @default.
• W2183685355 type Work @default.
• W2183685355 sameAs 2183685355 @default.
• W2183685355 citedByCount "107" @default.
• W2183685355 countsByYear W21836853552012 @default.
• W2183685355 countsByYear W21836853552013 @default.
• W2183685355 countsByYear W21836853552014 @default.
• W2183685355 countsByYear W21836853552016 @default.
• W2183685355 countsByYear W21836853552017 @default.
• W2183685355 countsByYear W21836853552018 @default.
• W2183685355 countsByYear W21836853552019 @default.
• W2183685355 countsByYear W21836853552020 @default.
• W2183685355 countsByYear W21836853552021 @default.
• W2183685355 countsByYear W21836853552022 @default.
• W2183685355 countsByYear W21836853552023 @default.
• W2183685355 crossrefType "journal-article" @default.
• W2183685355 hasAuthorship W2183685355A5035708680 @default.
• W2183685355 hasAuthorship W2183685355A5038055476 @default.
• W2183685355 hasAuthorship W2183685355A5048880494 @default.
• W2183685355 hasAuthorship W2183685355A5049461930 @default.
• W2183685355 hasAuthorship W2183685355A5053115428 @default.
• W2183685355 hasBestOaLocation W21836853552 @default.
• W2183685355 hasConcept C105702510 @default.
• W2183685355 hasConcept C119795356 @default.
• W2183685355 hasConcept C121608353 @default.
• W2183685355 hasConcept C126322002 @default.
• W2183685355 hasConcept C134018914 @default.
• W2183685355 hasConcept C142724271 @default.
• W2183685355 hasConcept C181199279 @default.
• W2183685355 hasConcept C2776530083 @default.
• W2183685355 hasConcept C2776907368 @default.
• W2183685355 hasConcept C2777546739 @default.
• W2183685355 hasConcept C2780474809 @default.
• W2183685355 hasConcept C28212737 @default.
• W2183685355 hasConcept C2994460389 @default.
• W2183685355 hasConcept C538909803 @default.
• W2183685355 hasConcept C55493867 @default.
• W2183685355 hasConcept C71924100 @default.
• W2183685355 hasConcept C86803240 @default.
• W2183685355 hasConceptScore W2183685355C105702510 @default.
• W2183685355 hasConceptScore W2183685355C119795356 @default.
• W2183685355 hasConceptScore W2183685355C121608353 @default.
• W2183685355 hasConceptScore W2183685355C126322002 @default.
• W2183685355 hasConceptScore W2183685355C134018914 @default.
• W2183685355 hasConceptScore W2183685355C142724271 @default.
• W2183685355 hasConceptScore W2183685355C181199279 @default.
• W2183685355 hasConceptScore W2183685355C2776530083 @default.
• W2183685355 hasConceptScore W2183685355C2776907368 @default.
• W2183685355 hasConceptScore W2183685355C2777546739 @default.
• W2183685355 hasConceptScore W2183685355C2780474809 @default.
• W2183685355 hasConceptScore W2183685355C28212737 @default.
• W2183685355 hasConceptScore W2183685355C2994460389 @default.
• W2183685355 hasConceptScore W2183685355C538909803 @default.
• W2183685355 hasConceptScore W2183685355C55493867 @default.
• W2183685355 hasConceptScore W2183685355C71924100 @default.
• W2183685355 hasConceptScore W2183685355C86803240 @default.

• next