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• W2183690999 abstract "Type 2 - DM may affect the mortality and outcome of cirrhotic patients. However, few studies assessing the prevalence and the impact of type 2 - DM on the outcome of cirrhotic patients are available. The prese nt study was performed to evaluate the rate of type 2 - DM and their impacts on the outcome of patients are available with liver cirrhosis. The study included 138 patients with liver cirrhosis, with and without diabetes at AI - Azhar and Tanta University Hosp itals between January 2009 and October 2010. Patients were divided into two groups; group I included 76 patients with type 2 - diabetes; group 11 included 62 patients without diabetes. History and clinical examination were performed to all patients with spec ial emphasis on diabetes : Child's Pugh Score, and complications of liver cirrhosis. Liver and renal function tests, FBS, PPBS, HbAlc, a - feto protein, CBC, viral markers and abdominal ultrasongraphy were performed to all patients. The incidence of type 2 - di abetes (group I) was 76/138 (55%) most of them had HCV infection (56/76 =73.5%) and 20% had ~V infection; in contrast to non - diabetic patients had IiBV infection 31/62(50%) and 27/62 (43.5%) had HCV infection. Group I patients had severe liver disease (Chi ld Pugh score C) than group 11 ( p <0.001). Serum levels of hemoglobin, platelet and albumin were significantly lower while serum levels of bilirubin, ALT, AST, FBS, PPBS, creatinine, HbAlc, a - feto protein, BM! and HOMA IR were significantly higher in group I. All liver cirrhosis complications were significantly higher in group I. Using Multiple regression analysis the following variables were predictors of death in patients with liver cirrhosis; high serum levels of HbAlc (OR=4.5, 95% CI=2.5 - 9.5, r=0.680, p < 0.01), Child - Pugh class C (OR=4.5, 95% CI=2.2 - 8.5, r=0.620, p <0.01), low serum levels of albumin (OR=3.8, 95% CI=1.3 - 5.7, r=0.580, p <0.01) and high serum levels of creatinine (OR=3.2, 95% CI=1.1 - 3.2, r=0.500, p <0.01).Conclusions: The incidence of DM was significantly higher in cirrhotic patients (55%) and significantly increases their complications and mortality rate. High HbAlc, Child - Pugh class C, low serum levels of albumin and high serum levels of creatinine were impendent predictors of death. ( Gamal A. Eltohamy and Hassan E. EI - Batae . Outcome of Patients with Liver Cirrhosis and Type 2 - Diabetes . J" @default.
• W2183690999 created "2016-06-24" @default.
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• W2183690999 date "2013-01-01" @default.
• W2183690999 modified "2023-09-27" @default.
• W2183690999 title "Outcome of Patients with Liver Cirrhosis and Type 2 - Diabetes" @default.
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