Matches in SemOpenAlex for { <https://semopenalex.org/work/W2183695321> ?p ?o ?g. }
- W2183695321 endingPage "800" @default.
- W2183695321 startingPage "782" @default.
- W2183695321 abstract "A fundamental goal of epidemiologic research is to investigate the relationship between exposures and disease risk. Cases of the disease are often considered a single outcome and assumed to share a common etiology. However, evidence indicates that many human diseases arise and evolve through a range of heterogeneous molecular pathologic processes, influenced by diverse exposures. Pathogenic heterogeneity has been considered in various neoplasms such as colorectal, lung, prostate, and breast cancers, leukemia and lymphoma, and non-neoplastic diseases, including obesity, type II diabetes, glaucoma, stroke, cardiovascular disease, autism, and autoimmune disease. In this article, we discuss analytic options for studying disease subtype heterogeneity, emphasizing methods for evaluating whether the association of a potential risk factor with disease varies by disease subtype. Methods are described for scenarios where disease subtypes are categorical and ordinal and for cohort studies, matched and unmatched case–control studies, and case–case study designs. For illustration, we apply the methods to a molecular pathological epidemiology study of alcohol intake and colon cancer risk by tumor LINE-1 methylation subtypes. User-friendly software to implement the methods is publicly available. Copyright © 2015 John Wiley & Sons, Ltd." @default.
- W2183695321 created "2016-06-24" @default.
- W2183695321 creator A5038373228 @default.
- W2183695321 creator A5039645415 @default.
- W2183695321 creator A5046508036 @default.
- W2183695321 creator A5049212930 @default.
- W2183695321 creator A5067206764 @default.
- W2183695321 creator A5068835941 @default.
- W2183695321 creator A5069872243 @default.
- W2183695321 creator A5074259922 @default.
- W2183695321 creator A5074516418 @default.
- W2183695321 creator A5076818447 @default.
- W2183695321 creator A5078859928 @default.
- W2183695321 creator A5089191285 @default.
- W2183695321 date "2015-12-01" @default.
- W2183695321 modified "2023-10-15" @default.
- W2183695321 title "Statistical methods for studying disease subtype heterogeneity" @default.
- W2183695321 cites W1558773828 @default.
- W2183695321 cites W1900950561 @default.
- W2183695321 cites W1910950825 @default.
- W2183695321 cites W1919179006 @default.
- W2183695321 cites W1964605289 @default.
- W2183695321 cites W1964639377 @default.
- W2183695321 cites W1966738726 @default.
- W2183695321 cites W1978014946 @default.
- W2183695321 cites W1979483524 @default.
- W2183695321 cites W1981548531 @default.
- W2183695321 cites W1984486655 @default.
- W2183695321 cites W1994225895 @default.
- W2183695321 cites W2001594506 @default.
- W2183695321 cites W2005709809 @default.
- W2183695321 cites W2005725365 @default.
- W2183695321 cites W2011995257 @default.
- W2183695321 cites W2014520026 @default.
- W2183695321 cites W2016633092 @default.
- W2183695321 cites W2019527553 @default.
- W2183695321 cites W2022815972 @default.
- W2183695321 cites W2025344263 @default.
- W2183695321 cites W2029446677 @default.
- W2183695321 cites W2030632931 @default.
- W2183695321 cites W2035159480 @default.
- W2183695321 cites W2041055738 @default.
- W2183695321 cites W2043140092 @default.
- W2183695321 cites W2046458419 @default.
- W2183695321 cites W2050856993 @default.
- W2183695321 cites W2052657862 @default.
- W2183695321 cites W2060427373 @default.
- W2183695321 cites W2060622076 @default.
- W2183695321 cites W2065725486 @default.
- W2183695321 cites W2066948394 @default.
- W2183695321 cites W2067902503 @default.
- W2183695321 cites W2069031417 @default.
- W2183695321 cites W2071441216 @default.
- W2183695321 cites W2073023604 @default.
- W2183695321 cites W2080494723 @default.
- W2183695321 cites W2080716821 @default.
- W2183695321 cites W2083867485 @default.
- W2183695321 cites W2090134169 @default.
- W2183695321 cites W2090556855 @default.
- W2183695321 cites W2092648747 @default.
- W2183695321 cites W2093272868 @default.
- W2183695321 cites W2097761061 @default.
- W2183695321 cites W2101037478 @default.
- W2183695321 cites W2101807916 @default.
- W2183695321 cites W2105381419 @default.
- W2183695321 cites W2108016142 @default.
- W2183695321 cites W2112983644 @default.
- W2183695321 cites W2114486584 @default.
- W2183695321 cites W2119426335 @default.
- W2183695321 cites W2119975203 @default.
- W2183695321 cites W2121685690 @default.
- W2183695321 cites W2123702717 @default.
- W2183695321 cites W2125241873 @default.
- W2183695321 cites W2125905177 @default.
- W2183695321 cites W2125957956 @default.
- W2183695321 cites W2126602143 @default.
- W2183695321 cites W2128230897 @default.
- W2183695321 cites W2128623472 @default.
- W2183695321 cites W2128708422 @default.
- W2183695321 cites W2131430783 @default.
- W2183695321 cites W2132518753 @default.
- W2183695321 cites W2133374268 @default.
- W2183695321 cites W2136264604 @default.
- W2183695321 cites W2139087961 @default.
- W2183695321 cites W2139168999 @default.
- W2183695321 cites W2140259403 @default.
- W2183695321 cites W2143030306 @default.
- W2183695321 cites W2143501119 @default.
- W2183695321 cites W2144022045 @default.
- W2183695321 cites W2144114448 @default.
- W2183695321 cites W2149804497 @default.
- W2183695321 cites W2152196433 @default.
- W2183695321 cites W2152995044 @default.
- W2183695321 cites W2153039923 @default.
- W2183695321 cites W2154489588 @default.
- W2183695321 cites W2157708739 @default.
- W2183695321 cites W2159575833 @default.
- W2183695321 cites W2161089575 @default.