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- W2183695396 abstract "We report a young Kuwaiti gentleman who presented with severe diabetic ketoacidosis (DKA) associated with atypical antipsychotic drug olanzapine. The current medical literature suggests that atypical antipsychotic drugs, including olanzapine lead to weight gain, insulin resistance, impaired glucose tolerance, diabetes mellitus (DM) and rarely patient may present with serious side effects like DKA. Clinicians are urged to monitor the emergence of metabolic risk factors periodically and remain aware of potentially serious effects like DKA in schizophrenic patients taking olanzapine. Bahrain Med Bull 2007; 29(4): Antipsychotic medications are the mainstay of treatment for psychotic illnesses. The conventional or first generation antipsychotics (FGAs) were introduced in 1950 and are effective in treating positive symptoms of psychosis. FGAs do not, however, adequately alleviate negative symptoms (e.g., withdrawal, apathy, poverty of speech), cognitive impairment, and affective symptoms. With the introduction of the atypical antipsychotics in late 1980s, the use of these medications has soared. These newer antipsychotics have many notable benefits compared with their earlier counterparts, but their use has been associated with reports of dramatic weight gain, diabetes mellitus, even acute metabolic decompensation, e.g., DKA and atherogenic lipid profile (increased LDL cholesterol and triglyceride levels and decreased HDL cholesterol) 1 . There are few reports in the literature indicating that Olanzapine, a newer antipsychotic agent, is associated with onset or worsening of pre-existing diabetes mellitus, weight gain and metabolic syndrome. However, severe DKA as a presenting manifestation is very rarely reported in the literature. Increased physician awareness about the emergence of insulin resistance metabolic syndrome and precipitation of life threatening side effects like DKA with atypical antipsychotic agents is of great importance. The aim of this paper is to report the case of a young Kuwaiti gentleman who presented with severe diabetic ketoacidosis (DKA) associated with atypical antipsychotic drug olanzapine." @default.
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- W2183695396 date "2007-01-01" @default.
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- W2183695396 title "Severe Diabetic Ketoacidosis Precipitated by an Atypical Antipsychotic Drug" @default.
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