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- W2183696101 abstract "In recent years, drug-induced pneumonia has attracted increased attention in Japan, following adverse effects that were found to occur with the use of gefitinib and leflunomide. It was even determined that the same agent might produce different imaging patterns of lung injury, and fatal lung disorders have been associated with imaging patterns and pathologic findings of diffuse alveolar damage. Epidemiological research has revealed that drug-induced lung disease of any type is associated with the presence of common risk factors of occurrence and poor prognosis. For example, drug-induced lung disease is more likely to occur when there is preexisting interstitial pneumonia. International comparisons have suggested that drug-induced lung disease is more common in Japan than in many other countries. However, because the physicians who prescribe drugs have a different specialty from that of those who assess the side effects of the drugs, there have been barriers to research, and the detection of adverse events may be delayed. Gefitinib, a molecular targeting drug, has been found to be highly effective for lung cancer that presents particular gene mutations in EGFR tyrosine kinase, and it has been confirmed that this mutation is frequent among the Japanese population. In the globalized competition of drug development, elucidation of the race-specificity in drug-induced lung disease is as important a topic as the efficacy of drugs. It is necessary to ensure the safety of medical care by understanding the mechanisms of such lung injury." @default.
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- W2183696101 date "2007-01-01" @default.
- W2183696101 modified "2023-09-26" @default.
- W2183696101 title "From the Japanese Association of Medical Sciences" @default.
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