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• W2183696369 startingPage "965" @default.
• W2183696369 abstract "The cortical regions of the brain are laminated as a result of directed migration of precursor cells along glia during development. Previously, we have used an assay system to identify astrotactin as a neuronal ligand for migration on glial fibers. To examine the function of astrotactin in vivo, we generated a null mutation by targeted gene disruption. The cerebella of astrotactin null mice are approximately 10% smaller than wild type. In vitro and in vivo cerebellar granule cell assays show a decrease in neuron-glial binding, a reduction in migration rates and abnormal development of Purkinje cells. Consequences of this are poorer balance and coordination. Thus, astrotactin functions in migration along glial processes in vivo, a process required for generating laminar structures and for the development of synaptic partner systems." @default.
• W2183696369 created "2016-06-24" @default.
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• W2183696369 date "2002-02-15" @default.
• W2183696369 modified "2023-09-26" @default.
• W2183696369 title "Mice that lack astrotactin have slowed neuronal migration" @default.
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• W2183696369 doi "https://doi.org/10.1242/dev.129.4.965" @default.
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