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- W2183709124 abstract "The objective this study was to summarize long-term risks associated with bisphosphonate therapy. Search of relevant medical publications for data from clinical trials, trial extensions, observational studies and post-marketing reports. Trial extensions and modifications did not reveal significant long-term safety issues. Observational data suggest at least as many benefits as risks. Post-marketing reports of musculoskeletal pain, osteonecrosis of the jaw and atypical femur fractures have been widely circulated in the lay press. Most focus on long-terms risks has been on osteonecrosis of the jaw and atypical femur fractures which occur in patients who have not received bisphosphonate therapy but may be more frequent (though still uncommon) in patients who have been on treatment for 5 years or longer. Lower-risk patients may be able to stop treatment after 3-5 years for a “drug holiday,” which mitigates these long-term risks; for higher risk patients, therapy through 6-10 years appears to be advisable and offers more bene" @default.
- W2183709124 created "2016-06-24" @default.
- W2183709124 creator A5090665248 @default.
- W2183709124 date "2014-01-01" @default.
- W2183709124 modified "2023-09-27" @default.
- W2183709124 title "Long-term risks of bisphosphonate therapy Riscos do tratamento a longo prazo com bisfosfonatos" @default.
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