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- W2183711234 abstract "ABSTRACT Agene, PDE2, hasbeenclonedfromtheyeast Saccharomyces cerevisiae that, when present in high copy, reverses the phenotypic effects of RAS2vad9, amutantformof theRAS2gene that renders yeast cells sensitive to heatshockand starvation. It has previously been shown that the RAS proteins are potent activators ofyeast adenylate cyclase. We report herethatPDE2encodesa high-affinity cAMP phospho- diesterase that shares sequence homology with animal cell phosphodiesterases. These results therefore imply that the effects of RAS2vi19 aremediated through its changes incAMPconcentration. Ourlaboratory group has been studying the mechanism ofgrowth control in the yeast Saccharomyces cerevisiae withparticular concentration on the functions ofthe RAS] andRAS2genes, which are structurally andfunctionally homol-ogous to the ras oncogenesofmammaliancells(1-4). Atleast one RASI or RAS2geneis requiredforthecontinuedgrowthofyeastcells (5, 6) andit hasbeenshownthatRASgenes are essential controlling elementsfor adenylate cyclase in yeast(2, 7, 8)." @default.
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- W2183711234 date "1986-01-01" @default.
- W2183711234 modified "2023-09-27" @default.
- W2183711234 title "Cloning andcharacterization ofthehigh-affinity cAMP phosphodiesterase" @default.
- W2183711234 hasPublicationYear "1986" @default.
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