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- W2183776133 abstract "There are evidences which suggest that HLA-G molecule plays an important role in immune tolerance, protecting the potentially allogenic fetus from maternal immune attack. Regulation of HLA-G expression is not well characterized; however, studies suggest a possible role of glucocorticoids in modulation of HLA-G gene expression. Therefore, we tested this hypothesis by inducing the HLA-G expression levels in full term placenta using two glucocorticoids-Dexamethasone and Hydrocortisone, JEG-3 and JAR cell lines were used as a positive and negative controls. Cultured trophoblast cells were treated with Dexamethasone and hydrocortisone. HLA-G transcription was determined by semi-quantitative RT-PCR. Choriocarcinoma JEG-3 (HLA-G+ve) and JAR (HLA-G-ve) cell lines were obtained from American Type Culture Collection (ATCC). The level of HLA-G mRNA transcripts in trophoblast cells were elevated by Dexamethasone and hydrocortisone in dose and time dependent manners. Glucocorticoids have an up-regulatory effect on HLA-G transcripts in trophoblast cells." @default.
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- W2183776133 date "2010-12-01" @default.
- W2183776133 modified "2023-09-28" @default.
- W2183776133 title "Effect of Glucocorticoids on Transcriptional Status of HLA-G in Human Trophoblast Cells from Full Term Placenta" @default.
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- W2183776133 doi "https://doi.org/10.1080/09723757.2010.11886109" @default.
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