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- W2183808301 abstract "2 Abstract: Hepatitis C is a major health problem. In Egypt, the prevalence rate reaches 15% in rural areas. An important and striking feature of hepatitis C is its tendency towards chronicity that may lead to cirrhosis and hepatocellular carcinoma. Because of the morbidity and expense of liver biopsy, it is important to consider whether noninvasive testing such as ALT and HCV RNA quantification provides comparable information with respect to the level of liver disease activity. In this study we tried to correlate between the degree of necroinflammatory injury and stage of fibrosis with PCR and liver enzymes (ALT, AST & AP) in chronic hepatitis C. This study includes 90 untreated patients with a serological and histological diagnosis of chronic HCV infection. Serological evaluation was performed using Real-Time PCR. ALT, AST and AP levels were measured by automatic analyzer. Ishak scoring system was used for grading necroinflammatory injury and staging of fibrosis. Most of patients (76.7%) had mild degree of hepatitis. The majority of cases showed moderate degree of fibrosis. Serum Levels of both ALT and AST correlated with the grades of liver necroinflammatory activity but not the stage. Alkaline phosphatase levels as well as HCV-RNA titre correlated with neither the grades of liver necroinflammatory activity nor the stage of liver fibrosis. In conclusion, liver biopsy remains an important tool in the appropriate selection of patients for whom therapy can successfully treat." @default.
- W2183808301 created "2016-06-24" @default.
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- W2183808301 date "2014-01-01" @default.
- W2183808301 modified "2023-09-24" @default.
- W2183808301 title "Correlation of Liver Biopsy with Liver Enzymes and PCR among Egyptian Patients with Chronic Hepatitis C" @default.
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