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• W2183908897 abstract "Rheumatoid Arthritis (RA) is an autoimmune disease characterized by chronic synovial inflammation and disability.The most widely used Disease-Modifying Antirheumatic Drug (DMARD) is methotrexate and it continues to be the goldstandard. However, the use of high-dose methotrexate is associated with severe adverse effects. Iguratimod, which iscurrently used in clinics in China and Japan, is a novel oral DMARD for the treatment of RA. In this study, the effectof combination of methotrexate and iguratimod on murine Collagen-Induced Arthritis (CIA) and its mechanism wasdetermined. Oral administration of iguratimod (3 mg/kg, 10 mg/kg) combined with methotrexate (1 mg/kg) potentlyblocked CIA development and delayed its progression, which was stronger than iguratimod or methotrexate used alone.Furthermore, infiltration of inflammatory cells into the synovium was remarkably inhibited by combination therapy andimportantly, no bone erosion and joint destructions were observed in combination therapy group. In addition, combinedadministration of these two DMARDs suppressed production of cytokines (IL-17, IFN-γ, IL-6 and TNF-α) and antibodies(IgG and IgG2b) in serum, as well as humoral and cellular responses in CIA mice. Consistent with its effects in vivo,iguratimod combined with methotrexate significantly suppressed T and B cells responses in vitro. Taken together, ourfindings suggest that combination treatment with iguratimod and methotrexate should be an intriguing and preferabletherapeutic strategy for treating RA." @default.
• W2183908897 created "2016-06-24" @default.
• W2183908897 date "2014-01-01" @default.
• W2183908897 modified "2023-09-26" @default.
• W2183908897 title "Iguratimod Synergizes with Methotrexate to Exert Anti-Inflammatory and Bone-Protective Effect and Block the Progression of Collagen-Induced Arthritis in Mices" @default.
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• W2183908897 doi "https://doi.org/10.4172/2167-0501.1000135" @default.
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