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• W2183922433 abstract "The objective of the study was to explore the anti-inflammatory effect of methanolic extract of stem bark of Careya arborea Roxb, a plant used locally in India for various painful inflammatory conditions; using chronic inflammatory model of Complete Freund's Adjuvant (CFA) induced chronic inflammation in rats. The anti-inflammatory activities of methanol extract of C. arborea (MECA) at doses of 100 and 200 mg/kg, p.o. were investigated in CFA induced inflammation using Indomethacin (5 mg/kg, p.o.) as reference drug. Inflammation was induced by injecting 0.1 ml of CFA containing 5 mg/ml of heat killed Mycobacterium tuberculosis into the sub plantar region of the left hind paw. Treatment with the extract and standard was started on the day of induction of inflamogens and continued up to 28 days. The effect of MECA on the production of nitric oxide, myeloperoxidase, gamma glutamyl transferase, malondialdehyde and C-reactive protein were determined. Oral administration of MECA (100 and 200 mg/kg) significantly reduced paw volume and tibio-tarsal joint diameter (p < 0.001) when compared with CFA control. The score of arthritic index in groups received methanolic extract (100 and 200 mg/kg) and Indomethacin (5 mg/kg) treatment decreased significantly when compared with CFA control (p < 0.01, p < 0.001 and p < 0.001, respectively). Moreover, the levels of nitric oxide, myeloperoxidase, gamma glutamyl transferase, malondialdehyde and C-reactive protein were significantly down-regulated after administration of methanolic extract of C. arborea. The biochemical findings were further supported by the radiographic changes. In conclusion, our findings suggest that methanolic extract of C. arborea stem bark exhibited potent anti-inflammatory effects in CFA induced chronic inflammation." @default.
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• W2183922433 date "2014-01-01" @default.
• W2183922433 modified "2023-09-26" @default.
• W2183922433 title "Evaluation of Anti-inflammatory Effect of Careya arborea in CFA Induced Chronic Inflammation" @default.
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