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- W2183935376 abstract "A rapid and sensitive liquid chromatography tandem mass spectrometry method has been developed and validated for the simultaneous determination of metformin and letrozole in human plasma. The solid-phase extraction technique was used for the extraction of metformin and letrozole from human plasma. Anastrozole was used as the internal standard (IS). Chromatography was performed on a Hypurity C18, 5 μm, 50 mm × 4.6 mm column, with the mobile phase consisting of 5mM ammonium formate and acetonitrile (in a 20:80 ratio), followed by detection using mass spectrometry. The method involves a simple reversed isocratic chromatography condition and mass spectrometry detection, which enables detection at sub-nanogram levels. The method was validated and the lower limit of quantification for metformin and letrozole was found to be 5.0 ng mL −1 and 0.5 ng mL respectively. The mean recovery for letrozole and metformin ranged from 90.1 to 95.6%. This method increased the sensitivity and selectivity; resulting in high-throughput analysis of letrozole and metformin using single IS in a single experiment for bioequivalence studies, with a chromatographic run time of 2.5 min only." @default.
- W2183935376 created "2016-06-24" @default.
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- W2183935376 date "2013-01-01" @default.
- W2183935376 modified "2023-09-26" @default.
- W2183935376 title "APPLICATION OF SENSITIVE, RAPID AND VALIDATED LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY METHOD FOR SIMULTANEOUS DETERMINATION OF LETROZOLE AND METFORMIN IN HUMAN PLASMA." @default.
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