Matches in SemOpenAlex for { <https://semopenalex.org/work/W2183947646> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2183947646 abstract "Transient global ischemia in rodents induces delayed death of hippocampal CA1 neurons, as well as in some hilar neurons of the dentate gyrus, medium aspiny neurons of the striatum, pyramidal neurons in neocortical layers II, V and VI, and Purkinje neurons of the cerebellum. In contrast to focal ischemia that mimics regional stroke in humans, this model of global ischemia mimics the brain injury that occurs after human cardiac arrest. Early events include caspase activation, cleavage of anti-death Bcl-2 family proteins and large mitochondrial channel activity. Genetically engineered mice provide opportunities for study such as the knock-in mouse expressing a caspase-resistant form of Bcl-xL found to exhibit markedly reduced mitochondrial channel activity and reduced vulnerability to ischemia-induced neuronal death1. It is therefore relevant to adapt and develop a simple protocol for producing transient global ischemia in mouse2. The two-vessel occlusion model has been specifically developed to provide optimal outcomes in mouse and offers several advantages over the four-vessel occlusion model traditionally used in rat including the relative ease of the procedure as well as only a single day of surgery. However it should be noted that this procedure has a higher morbidity rate compared to other ischemia models as well as a higher degree of variability. These two disadvantages necessitate the use of a larger cohort of animals, which for many healthy breeding transgenic animals is a non-deterring factor." @default.
- W2183947646 created "2016-06-24" @default.
- W2183947646 creator A5017323656 @default.
- W2183947646 creator A5044683201 @default.
- W2183947646 creator A5050171363 @default.
- W2183947646 creator A5060297696 @default.
- W2183947646 date "2012-01-01" @default.
- W2183947646 modified "2023-10-16" @default.
- W2183947646 title "Mouse Transient Global Ischemia Two-Vessel Occlusion Model" @default.
- W2183947646 cites W2019732053 @default.
- W2183947646 cites W2027625804 @default.
- W2183947646 doi "https://doi.org/10.21769/bioprotoc.262" @default.
- W2183947646 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4950949" @default.
- W2183947646 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27446974" @default.
- W2183947646 hasPublicationYear "2012" @default.
- W2183947646 type Work @default.
- W2183947646 sameAs 2183947646 @default.
- W2183947646 citedByCount "4" @default.
- W2183947646 countsByYear W21839476462019 @default.
- W2183947646 countsByYear W21839476462020 @default.
- W2183947646 countsByYear W21839476462023 @default.
- W2183947646 crossrefType "journal-article" @default.
- W2183947646 hasAuthorship W2183947646A5017323656 @default.
- W2183947646 hasAuthorship W2183947646A5044683201 @default.
- W2183947646 hasAuthorship W2183947646A5050171363 @default.
- W2183947646 hasAuthorship W2183947646A5060297696 @default.
- W2183947646 hasBestOaLocation W21839476462 @default.
- W2183947646 hasConcept C102230213 @default.
- W2183947646 hasConcept C104317684 @default.
- W2183947646 hasConcept C126322002 @default.
- W2183947646 hasConcept C127413603 @default.
- W2183947646 hasConcept C141035611 @default.
- W2183947646 hasConcept C148762608 @default.
- W2183947646 hasConcept C169760540 @default.
- W2183947646 hasConcept C2776268601 @default.
- W2183947646 hasConcept C2776464000 @default.
- W2183947646 hasConcept C2780062018 @default.
- W2183947646 hasConcept C2780222073 @default.
- W2183947646 hasConcept C2780645631 @default.
- W2183947646 hasConcept C513476851 @default.
- W2183947646 hasConcept C541997718 @default.
- W2183947646 hasConcept C54355233 @default.
- W2183947646 hasConcept C71924100 @default.
- W2183947646 hasConcept C78519656 @default.
- W2183947646 hasConcept C86803240 @default.
- W2183947646 hasConcept C95444343 @default.
- W2183947646 hasConceptScore W2183947646C102230213 @default.
- W2183947646 hasConceptScore W2183947646C104317684 @default.
- W2183947646 hasConceptScore W2183947646C126322002 @default.
- W2183947646 hasConceptScore W2183947646C127413603 @default.
- W2183947646 hasConceptScore W2183947646C141035611 @default.
- W2183947646 hasConceptScore W2183947646C148762608 @default.
- W2183947646 hasConceptScore W2183947646C169760540 @default.
- W2183947646 hasConceptScore W2183947646C2776268601 @default.
- W2183947646 hasConceptScore W2183947646C2776464000 @default.
- W2183947646 hasConceptScore W2183947646C2780062018 @default.
- W2183947646 hasConceptScore W2183947646C2780222073 @default.
- W2183947646 hasConceptScore W2183947646C2780645631 @default.
- W2183947646 hasConceptScore W2183947646C513476851 @default.
- W2183947646 hasConceptScore W2183947646C541997718 @default.
- W2183947646 hasConceptScore W2183947646C54355233 @default.
- W2183947646 hasConceptScore W2183947646C71924100 @default.
- W2183947646 hasConceptScore W2183947646C78519656 @default.
- W2183947646 hasConceptScore W2183947646C86803240 @default.
- W2183947646 hasConceptScore W2183947646C95444343 @default.
- W2183947646 hasIssue "18" @default.
- W2183947646 hasLocation W21839476461 @default.
- W2183947646 hasLocation W21839476462 @default.
- W2183947646 hasLocation W21839476463 @default.
- W2183947646 hasLocation W21839476464 @default.
- W2183947646 hasOpenAccess W2183947646 @default.
- W2183947646 hasPrimaryLocation W21839476461 @default.
- W2183947646 hasRelatedWork W1942220934 @default.
- W2183947646 hasRelatedWork W1991905088 @default.
- W2183947646 hasRelatedWork W1994424364 @default.
- W2183947646 hasRelatedWork W2046024114 @default.
- W2183947646 hasRelatedWork W2076135710 @default.
- W2183947646 hasRelatedWork W2081792644 @default.
- W2183947646 hasRelatedWork W2115351128 @default.
- W2183947646 hasRelatedWork W2183947646 @default.
- W2183947646 hasRelatedWork W2474425639 @default.
- W2183947646 hasRelatedWork W2949055990 @default.
- W2183947646 hasVolume "2" @default.
- W2183947646 isParatext "false" @default.
- W2183947646 isRetracted "false" @default.
- W2183947646 magId "2183947646" @default.
- W2183947646 workType "article" @default.