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- W2183992106 abstract "The diagnosis of idiopathic hypereosinophilic syndrome is one of exclusion, requiring significant unexplained eosinophilia which persists for at least 6 months and is associated with tissue damage. The relationship of this condition to eosinophilic leukaemia remains controversial. In some patients who present with hypereosinophilia and damage to the heart and other tissues the condition can be shown to be reactive. In others a diagnosis of eosinophilic leukaemia can be made when an increase of blast cells or a clonal cytogenetic abnormality is detected. Other cases which fit the definition of idiopathic hypereosinophilic syndrome can be recognized in retrospect as eosinophilic leukaemia when there is subsequently development of a clonal cytogenetic abnormality or of acute myeloblastic leukaemia or granulocytic sarcoma. In a small number of patients other mechanism of eosinophilia have been demonstrated with secretion of cytokines by T cells, sometimes a clonal population of T cell, being demonstrated. Chronic eosinophilic leukaemia has been associated with a number of cytogenetic abnormalities including trisomy 8, isochromosome 17q, monosomy 7 and t (5;12) (q31-q33;p12-13). The most specific association is with t(5;12). Cytogenetic analysis is recommended in cases of unexplained eosinophilia." @default.
- W2183992106 created "2016-06-24" @default.
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- W2183992106 date "1996-01-01" @default.
- W2183992106 modified "2023-09-26" @default.
- W2183992106 title "When is the 'idiopathic' hypereosinophilic syndrome eosinophilic leukaemia?" @default.
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