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- W2183996909 abstract "Introduction: Very few formulations are available, at present, from which the drug is absorbed uniformly, so that safe and effective blood level of the drug could be maintained for a prolonged period. Considering this limitation, a suspension of Ciprofloxacin (drug) has been prepared for the present study using mucoadhesive HPMC as a polymer. Materials and Methods: The ultrasonication method has been used for the preparation of mucoadhesive suspension of Ciprofloxacin in which HPMC has been incorporated. The chemical interaction between Ciprofloxacin and polymer in the formulation has been studied by FTIR and Raman Spectroscopic analyses. Results: From the spectral interpretation, it has been found that in formulation, the carboxylic groups of Ciprofloxacin and hydroxyl groups of HPMC undergo chemical interaction, leading to esterification and hydrogen bonding. Conclusion: The formation of micellies due to esterification and hydrogen bonding causes more drug entrapment and a stable formulation. Due to that the formulation of Ciprofloxacin may give better controlled release and mucoadhesive action in the gastrointestinal tract. Hence, HPMC could be considered as an effective carrier for Ciprofloxacin." @default.
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- W2183996909 date "2012-01-01" @default.
- W2183996909 modified "2023-09-27" @default.
- W2183996909 title "SPECTROSCOPIC INVESTIGATIONS OF A CIPROFLOXACIN / HPMC MUCOADHESIVE SUSPENSION Research Article" @default.
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